Panacea Index Logo

Command Palette

Search for a command to run...

Progress of researches on mechanisms of acupuncture therapy in the treatment of lumbar disc herniation.

Zhen ci yan jiu = Acupuncture research
January 1, 1970
Xue-Shi DI et al. (11 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to summarize the mechanisms by which acupuncture improves symptoms of lumbar intervertebral disc herniation (LDH) based on recent studies.

Results Summary

Acupuncture was found to improve LDH symptoms through multiple mechanisms, including delaying disc degeneration, maintaining spinal stability, regulating inflammation and immune response, modulating neural function, and relieving pain. The study highlights acupuncture's potential to address various pathological aspects of LDH.

Population

Patients with lumbar intervertebral disc herniation (LDH).

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (26)
InterventionDirectionEndpointPopulationDosageImpactClaim #
acupuncture
increase
symptoms of LDH
LDH patients
-
can improve
#1
acupuncture
decrease
intervertebral disc degeneration
-
-
delaying
#2
acupuncture
decrease
expressions of matrix metalloproteinase (MMP)-3 and MMP-4
-
-
down-regulating
#3
acupuncture
increase
expressions of diosaccharides and polyglycoprotein
-
-
up-regulating
#4
acupuncture
decrease
apoptosis of nucleus pulposus cells
-
-
inhibiting
#5
acupuncture
increase
mitochondrial autophagy of nucleus pulposus cells
-
-
promoting
#6
acupuncture
increase
spinal column stability
-
-
maintaining
#7
acupuncture
decrease
rachiasmus
-
-
relieving
#8
acupuncture
increase
lumbar flexor and extensor muscle strength
-
-
improving
#9
acupuncture
decrease
degree of polyfidus edema and fat infiltration
-
-
lowering
#10
acupuncture
increase
biomechanics of the spine
-
-
restoring
#11
acupuncture
neutral
inflammation
-
-
regulating
#12
acupuncture
decrease
production of proinflammatory factors
-
-
inhibiting
#13
acupuncture
increase
production of anti-inflammatory factors
-
-
increasing
#14
acupuncture
neutral
immune response
-
-
regulating
#15
acupuncture
increase
activity of T cells and other immune cells
-
-
promoting
#16
acupuncture
decrease
serum levels of MMP-3, transforming growth factor-β1 and prostaglandin E2
-
-
lowering
#17
acupuncture
increase
serum levels of IgA, IgG and IgM
-
-
raising
#18
acupuncture
increase
immune function
-
-
improving
#19
acupuncture
neutral
neural structure and function
-
-
modulating
#20
acupuncture
increase
myelin regeneration of sciatic nerve fibers
-
-
promoting
#21
acupuncture
decrease
edema of Schwann cells' cytoplasm and mitochondria
-
-
reducing
#22
acupuncture
increase
neural ultrastructure
-
-
improving
#23
acupuncture
increase
sensory and motor functions of peripheral nerves
-
-
improving
#24
acupuncture
decrease
lumbar pain
-
-
relieving
#25
acupuncture
decrease
expression of Ca
-
-
down-regulating
#26
Abstract

Lumbar intervertebral disc herniation (LDH) is a common and frequently-occurring disease, which usually causes lumbar and leg pain. Studies have shown that acupuncture can improve the symptoms of LDH patients. In the present paper, we summarize the progress of researches on the mechanisms of acupuncture underlying improvement of symptoms of LDH in recent 10 years from 1) delaying the intervertibral disc degeneration (by down-regulating the expressions of matrix metalloproteinase [MMP]-3 and MMP-4, up-regulating the expressions of diosaccharides and polyglycoprotein, inhibiting apoptosis and promoting mitochondrial autophagy of nucleus pulposus cells, etc.), 2) maintaining spinal column stability (by relieving rachiasmus and improving lumbar flexor and extensor muscle strength, lowering the degree of polyfidus edema and fat infiltration, and restoring the biomechanics of the spine), 3) regulating inflammation (by inhibiting the production of proinflammatory factors and increasing the production of anti-inflammatory factors, etc.), 4) regulating immune response (by promoting the activity of T cells and other immune cells, lowering serum levels of MMP-3, transforming growth factor-β1 and prostaglandin E2, raising serum levels of IgA, IgG and IgM to improve immune function ), 5) modulating neural structure and function (by promoting myelin regeneration of sciatic nerve fibers, and reducing the edema of Schwann cells' cytoplasm and mitochondria, and improving neural ultrastructure, and sensory and motor functions of peripheral nerves, etc.), 6) relieving lumbar pain (by down-regulating expression of Ca 腰椎间盘突出症(LDH)是临床常见病和多发病,是引起腰腿痛的常见原因,研究表明针灸能够改善LDH患者症状,临床疗效确切。本文通过检索近10年来针灸治疗LDH作用机制研究的相关文献,结果显示针刺治疗LDH与延缓椎间盘退变、维持脊柱稳定、调节炎性反应、调节免疫反应、调节神经结构和功能、镇痛及改善局部微循环等多种作用机制密切相关。本文对以上机制归纳总结,以期为临床应用针灸治疗LDH提供科学依据。.

Medical Subject Headings (MeSH)
HumansAcupuncture TherapyIntervertebral Disc DisplacementAnimalsLumbar Vertebrae
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality75/10
Citation Metrics
Total Citations1
Citations/Year1.0
Research Impact Scores
APT Score0.50
Weight Score0.69
Normalized Score0.69
Related Supplements
Progress of researches on mechanisms of acupuncture therapy ... | Panacea Index