Development of Malaysian-MIND diet scores for prediction of mild cognitive impairment among older adults in Malaysia.
Study Goal
The researchers aimed to develop a Malaysian version of the MIND diet (MY-MINDD) and investigate its association with Mild Cognitive Impairment (MCI) in older adults in Malaysia.
Results Summary
Higher adherence to the MY-MINDD diet was associated with reduced odds of MCI, with participants in the highest tertile of MY-MINDD scores showing significantly lower MCI risk (OR = 0.43, 95% CI: 0.26-0.72, p < 0.001). The diet included seven beneficial and four detrimental food groups for cognitive health.
Population
Older adults in Malaysia (average age 67.9 ± 4.7 years).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Mediterranean & Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) diet | decrease | MCI and Alzheimer's disease | older people | - | has shown promise in reducing the risk | #1 |
Malaysian version of the MIND diet (MY-MINDD) | decrease | MY-MINDD score | individuals with MCI | 6.0 ± 1.7 compared to those without MCI at 6.6 ± 1.6 | revealing a lower score in individuals with MCI | #2 |
Malaysian version of the MIND diet (MY-MINDD) | decrease | MCI | study participants | odds ratio (OR) = 0.43, 95% confidence interval (CI): 0.26-0.72 | linked to reduced odds | #3 |
stronger adherence to this diet | decrease | MCI | Malaysian older population | - | is linked to a reduced risk | #4 |
BACKGROUND: Mild Cognitive impairment (MCI) is a pre-demented state in the elderly populace. The Mediterranean & Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) diet has shown promise in reducing the risk of MCI and Alzheimer's disease in older people. Notably, the existing MIND diet is not adapted to the specific needs of older adults in Malaysia, considering distinct food cultures and availability. Consequently, this study aimed to develop the Malaysian version of the MIND diet (MY-MINDD) scores and investigate their association with MCI in the older adult populace of Malaysia. METHODS: A comprehensive pooled data analysis was conducted on combined data from 810 participants sourced from the longitudinal Long-Term Research Grant Scheme-Towards Useful Aging (LRGS-TUA) and Fundamental Research Grant Scheme (FRGS) studies. The MY-MINDD scores were developed by incorporating existing MIND diet food groups, their corresponding scoring mechanisms, and consideration of common Malaysian foods which are proven to be beneficial and detrimental to cognitive function. To substantiate the MY-MINDD scoring system, its association with MCI was evaluated using a series of validated neuropsychological test batteries. RESULTS: MY-MINDD consists of seven food groups promote brain health and four food groups exert negative cognitive outcomes. The study participants had an average age of 67.9 ± 4.7 years. The collective MY-MINDD score for all participants was 6.4 ± 0.1 (out of a maximum 11 points), revealing a lower score in individuals with MCI at 6.0 ± 1.7 compared to those without MCI at 6.6 ± 1.6 (p < 0.001). According to hierarchical multivariate binary logistic regression analysis, being in the highest tertile of MY-MINDD score was linked to reduced odds of MCI (odds ratio (OR) = 0.43, 95% confidence interval (CI): 0.26-0.72, p < 0.001) in the fully adjusted model in comparison to the lowest tertile. CONCLUSION: The development of the MY-MINDD scores for Malaysian older population revealed that a stronger adherence to this diet is linked to a reduced risk of MCI. Further substantiation of the MY-MINDD scores using more objective measures, such as neuroimaging approaches and other neuropsychological batteries, is necessary.