Review of the evidence of radioprotective potential of creatine and arginine as dietary supplements.
Study Goal
The researchers aimed to review existing data on the radiomodifying effects of l-arginine, particularly its potential protective role against oxidative stress caused by ionizing radiation.
Results Summary
The study summarized existing data suggesting l-arginine may have radiomodifying effects, though specific efficacy details were not highlighted in the abstract. The focus was primarily on creatine's radioprotective potential, with l-arginine mentioned as a secondary review topic.
Population
Not specified (abstract focuses on general experimental data and literature review).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Creatine | neutral | antioxidant, anti-apoptotic, and anti-inflammatory properties | - | - | exhibit | #1 |
Creatine | decrease | oxidative stress | - | - | protective action | #2 |
Creatine | decrease | oxidative stress | aging process, athletes' workouts, neurological diseases, toxic effects associated with xenobiotics and UV irradiation | - | protective effect | #3 |
Creatine | neutral | - | - | - | radioprotective potential | #4 |
Creatine | increase | survival rate | rats subjected to acute whole-body X-ray irradiation | - | radioprotective effect | #5 |
l-arginine | neutral | antioxidant, anti-apoptotic, and anti-inflammatory properties | - | - | exhibit | #6 |
l-arginine | decrease | oxidative stress | - | - | protective action | #7 |
l-arginine | neutral | - | - | - | radiomodifying effects | #8 |
PURPOSE: Creatine (Cr) and l-arginine are naturally occurring guanidino compounds, commonly used as ergogenic dietary supplements. Creatine and l-arginine exhibit also a number of non-energy-related features, such as antioxidant, anti-apoptotic, and anti-inflammatory properties, which contribute to their protective action against oxidative stress (OS). In this regard, there are a number of studies emphasizing the protective effect of Cr against OS, which develops in the process of aging, increased physical loads as part of athletes' workouts, as well as a number of neurological diseases and toxic effects associated with xenobiotics and UV irradiation. Against this backdrop, and since ionizing radiation causes OS in cells, leading to radiotoxicity, there is an increasing interest to understand whether Cr has the full potential to serve as an effective radioprotective agent. The extensive literature search did not provide any data on this issue. In this narrative review, we have summarized some of our own experimental data published over the last years addressing the respective radioprotective effects of Cr. Next, we have additionally reviewed the existing data on the radiomodifying effects of l-arginine presented earlier by other research groups. CONCLUSIONS: Creatine possesses significant radioprotective potential including: (1) radioprotective effect on the survival rate of rats subjected to acute whole-body X-ray irradiation in a LD