Vitamin D Supplementation for Patients with Dysmenorrhoea: A Meta-Analysis with Trial Sequential Analysis of Randomised Controlled Trials.
Study Goal
The researchers aimed to determine whether vitamin D supplementation reduces pain intensity in patients with dysmenorrhoea.
Results Summary
Vitamin D supplementation significantly decreased pain intensity in dysmenorrhoea patients compared to controls, with a pooled mean difference of -1.64 (95% CI: -2.27 to -1.00). The study included 11 RCTs involving 687 participants.
Population
Patients with dysmenorrhoea.
Effective Dosage
Not specified in the abstract.
Duration
Not specified in the abstract.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D | decrease | prostaglandin levels | - | - | reduces | #1 |
Vitamin D | decrease | inflammation | - | - | reduces | #2 |
vitamin D supplementation | decrease | pain intensity | patients with dysmenorrhoea | pooled mean difference, -1.64; 95% confidence interval, -2.27 to -1.00 | significantly decreased | #3 |
Vitamin D reduces prostaglandin levels and inflammation, making it a promising treatment option for dysmenorrhoea. However, its effects on pain intensity in different types of dysmenorrhoea remain unclear. We examined whether vitamin D supplementation decreases pain intensity in patients with dysmenorrhoea. The Cochrane Library, Embase, Google Scholar, Medline, and Scopus databases were searched from inception to 30 December 2023. Randomised controlled trials (RCTs) evaluating vitamin D supplementation effects on such patients were included. The primary and secondary outcomes were measured by the changes in pain intensity and rescue analgesic use, respectively. Pooled mean differences and rate ratios were calculated using a random-effect model; trial sequential analysis (TSA) was also performed. Overall, 11 studies involving 687 participants were included. Vitamin D supplementation significantly decreased pain intensity in patients with dysmenorrhoea compared with controls (pooled mean difference, -1.64; 95% confidence interval, -2.27 to -1.00;