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Caffeine ingestion compromises thermoregulation and does not improve cycling time to exhaustion in the heat amongst males.

European journal of applied physiology
August 1, 2024
Kevin John et al. (10 authors)
Journal ArticleRandomized Controlled TrialHuman StudyClinical
Study Details

Study Goal

The researchers aimed to investigate the effects of acute caffeine supplementation on cycling performance and thermoregulation in hot conditions.

Results Summary

Caffeine did not improve cycling time to exhaustion but increased heat production, sweat rate, and core temperature while decreasing thermal comfort. No significant change in perceived exertion was observed.

Population

12 healthy, caffeine-habituated, unacclimatised males.

Effective Dosage

5 mg/kg, single dose.

Duration

Acute (60 minutes post-ingestion).

Interactions

None mentioned.

Extracted Claims (11)
InterventionDirectionEndpointPopulationDosageImpactClaim #
acute caffeine supplementation
no change
cycling time to exhaustion (TTE)
12 healthy caffeine-habituated and unacclimatised males
no significant change
There was no effect of
#1
caffeine
increase
pulmonary oxygen uptake
12 healthy caffeine-habituated and unacclimatised males
by 7.4%
increased
#2
caffeine
increase
heat production
12 healthy caffeine-habituated and unacclimatised males
by 7.9%
increased
#3
caffeine
increase
whole-body sweat rate (WBSR)
12 healthy caffeine-habituated and unacclimatised males
by 21%
increased
#4
caffeine
increase
evaporative heat transfer
12 healthy caffeine-habituated and unacclimatised males
by 16.5%
increased
#5
caffeine
decrease
estimated skin blood flow
12 healthy caffeine-habituated and unacclimatised males
by 14.1%
decreased
#6
caffeine
increase
Core temperature
12 healthy caffeine-habituated and unacclimatised males
by 0.6%
was higher
#7
caffeine
decrease
thermal comfort
12 healthy caffeine-habituated and unacclimatised males
by - 18.3%
decreased
#8
caffeine
no change
rate of perceived exertion
12 healthy caffeine-habituated and unacclimatised males
no significant change
no changes in
#9
5 mg/kg of caffeine
no change
performance
participants
-
did not provide a performance benefit
#10
5 mg/kg of caffeine
increase
the thermal strain
participants
-
increased
#11
Abstract

PURPOSE: Caffeine is a commonly used ergogenic aid for endurance events; however, its efficacy and safety have been questioned in hot environmental conditions. The aim of this study was to investigate the effects of acute caffeine supplementation on cycling time to exhaustion and thermoregulation in the heat. METHODS: In a double-blind, randomised, cross-over trial, 12 healthy caffeine-habituated and unacclimatised males cycled to exhaustion in the heat (35 °C, 40% RH) at an intensity associated with the thermoneutral gas exchange threshold, on two separate occasions, 60 min after ingesting caffeine (5 mg/kg) or placebo (5 mg/kg). RESULTS: There was no effect of caffeine supplementation on cycling time to exhaustion (TTE) (caffeine; 28.5 ± 8.3 min vs. placebo; 29.9 ± 8.8 min, P = 0.251). Caffeine increased pulmonary oxygen uptake by 7.4% (P = 0.003), heat production by 7.9% (P = 0.004), whole-body sweat rate (WBSR) by 21% (P = 0.008), evaporative heat transfer by 16.5% (P = 0.006) and decreased estimated skin blood flow by 14.1% (P < 0.001) compared to placebo. Core temperature was higher by 0.6% (P = 0.013) but thermal comfort decreased by - 18.3% (P = 0.040), in the caffeine condition, with no changes in rate of perceived exertion (P > 0.05). CONCLUSION: The greater heat production and storage, as indicated by a sustained increase in core temperature, corroborate previous research showing a thermogenic effect of caffeine ingestion. When exercising at the pre-determined gas exchange threshold in the heat, 5 mg/kg of caffeine did not provide a performance benefit and increased the thermal strain of participants.

Medical Subject Headings (MeSH)
HumansCaffeineMaleBody Temperature RegulationAdultBicyclingHot TemperatureDouble-Blind MethodCross-Over StudiesYoung AdultOxygen ConsumptionSweating
Study Links
Quality Scores
Safety70
Efficacy30/10
Quality85/10
Citation Metrics
Total Citations2
Citations/Year2.0
Research Impact Scores
APT Score0.25
Weight Score2.80
Normalized Score0.57
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