Association of Fortification with Human Milk versus Bovine Milk-Based Fortifiers on Short-Term Outcomes in Preterm Infants-A Meta-Analysis.
Study Goal
The researchers aimed to compare short-term outcomes (death and NEC) in preterm infants fed an exclusive human milk diet fortified with human milk-derived fortifiers (HMFs) versus bovine milk fortifiers (BMFs).
Results Summary
The study found that mortality was significantly lower in infants fed with an HM-HMFs diet compared to those fed with BMFs (RR = 0.50, 95% CI = 0.26-0.94). The primary outcomes assessed were death and NEC (stage ≥ 2).
Population
Preterm infants with ≤28 weeks gestation and/or birthweight ≤ 1500 g.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
human milk-derived fortifiers (HMFs) compared with bovine milk fortifiers (BMFs) in preterm infants fed an exclusive human milk (HM) diet | decrease | Mortality | infants with ≤28 weeks gestation and/or birthweight ≤ 1500 g | RR = 0.50, 95% CI = 0.26-0.94 | was significantly lower | #1 |
This meta-analysis assessed short-term outcomes after using human milk-derived fortifiers (HMFs) compared with bovine milk fortifiers (BMFs) in preterm infants fed an exclusive human milk (HM) diet, either mother's own milk (MOM) or donor human milk (DHM). We searched PubMed, Embase, Google Scholar, CENTRAL and CINHAL between January 2015 and August 2023 for studies reporting outcomes in infants with ≤28 weeks gestation and/or birthweight ≤ 1500 g on an exclusive human milk diet fortified with HMF versus BMF. The primary outcomes were death and NEC (stage ≥ 2). Four studies with a total of 681 infants were included. Mortality was significantly lower in infants fed with an HM-HMFs diet (four studies, 681 infants; RR = 0.50, 95% CI = 0.26-0.94;