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An Overview of Contemporary and Future Therapeutic Strategies for Scalp Psoriasis.

Current drug targets
January 1, 2024
Bindu Soni et al. (7 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to review current and investigational treatments for scalp psoriasis, including the role of Vitamin D analogs in managing the condition.

Results Summary

The abstract indicates that Vitamin D analogs, as part of topical treatments, help manage scalp psoriasis by reducing inflammation and regulating skin cell growth, though the study highlights a general lack of well-tolerated and effective treatments for the condition.

Population

Patients with scalp psoriasis.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (7)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Topical treatments like corticosteroids and vitamin D analogs
decrease
scalp psoriasis
-
-
manage
#1
Topical treatments like corticosteroids and vitamin D analogs
decrease
inflammation
-
-
reducing
#2
Topical treatments like corticosteroids and vitamin D analogs
neutral
skin cell growth
-
-
regulating
#3
Tar-based shampoos, salicylic acid solutions, and moisturizers
decrease
scaling
-
-
control
#4
Phototherapy with UVB light
decrease
inflammation
-
-
reduces
#5
Recent advancements in topical therapies, phototherapy, systemic agents, and complementary therapies
decrease
scalp psoriasis
-
-
have shown promising results in managing
#6
biologics, specifically anti-IL-17 and anti-IL-23 drugs
decrease
scalp psoriasis
-
-
has seen significant improvements
#7
Abstract

Scalp psoriasis is a common manifestation of psoriasis that significantly impacts a patient's quality of life. About 80% of cases of psoriasis involve the scalp, making it the most frequently affected area of the body. The treatment of scalp psoriasis is particularly crucial because of its hard-to-treat nature and substantial adverse impacts on overall well-being. Along with the physical symptoms of discomfort and itching, psoriasis, especially when it affects the scalp, can cause severe psychological damage. Treating scalp psoriasis can be challenging due to its location and associated symptoms, such as scaling and pruritus, which is why various drugs have become widely used for refractory cases. Topical treatments like corticosteroids and vitamin D analogs manage scalp psoriasis by reducing inflammation and regulating skin cell growth. Tar-based shampoos, salicylic acid solutions, and moisturizers control scaling. Phototherapy with UVB light reduces inflammation. Severe cases may require systemic medications such as oral retinoids and immunosuppressants. While various therapies are accessible for scalp psoriasis, concerns arise due to their limited advantages and the absence of controlled studies assessing their effectiveness. Considering these challenges, there is a clear demand for innovative approaches to address this condition effectively. Recent advancements in topical therapies, phototherapy, systemic agents, and complementary therapies have shown promising results in managing scalp psoriasis. Also, the advent of biologics, specifically anti-IL-17 and anti-IL-23 drugs for scalp psoriasis, has seen significant improvements. The review highlights the lack of well-tolerated and effective treatments for scalp psoriasis and underscores the importance of further research in this area. The objective of this review is to clarify the different treatment options currently available or being investigated in clinical trials for managing scalp psoriasis.

Medical Subject Headings (MeSH)
HumansPsoriasisDermatologic AgentsQuality of LifePhototherapyScalpScalp Dermatoses
Study Links
Quality Scores
SafetyNot Assessed
Efficacy70/10
Quality65/10
Citation Metrics
Total Citations2
Citations/Year2.0
Research Impact Scores
APT Score0.25
Weight Score2.39
Normalized Score0.61
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