Changes in smoking use and subsequent lung cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.
Study Goal
The researchers aimed to examine the association between changes in smoking behavior (including intensity and duration) and lung cancer risk among male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.
Results Summary
The study found that reducing cigarette consumption and smoking duration lowered lung cancer risk, with greater reductions associated with lower risk. However, the abstract does not report specific findings related to Beta-Carotene's effects.
Population
Finnish male smokers aged 50-69 years.
Effective Dosage
Not specified in the abstract.
Duration
Follow-up visits occurred approximately every 4 months between 1985 and 1993, with lung cancer cases identified through 2012.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Reducing cigarettes per day | decrease | lung cancer risk | - | - | may lower the risk | #1 |
reducing an average of 5 cigarettes per day per year while smoking | decrease | lung cancer | Finnish male smokers aged 50-69 years | 20% | associated with a lower risk | #2 |
smoked at 50% of study visits | decrease | lung cancer | Finnish male smokers aged 50-69 years | RR = 0.72 | substantially lower risk | #3 |
smoked at 10% of study visits | decrease | lung cancer | Finnish male smokers aged 50-69 years | RR = 0.55 | substantially lower risk | #4 |
reducing smoking intensity (cigarettes per day while smoking) | decrease | lung cancer | Smokers | - | may lower their risk | #5 |
reducing the time they smoke | decrease | lung cancer | Smokers | - | may lower their risk | #6 |
quitting smoking completely | decrease | lung cancer | smokers | - | the most effective way to reduce their risk | #7 |
BACKGROUND: Reducing cigarettes per day may lower the risk of lung cancer compared with continuing to smoke at the same intensity. Other changes in smoking behaviors, such as increasing cigarette consumption or quitting for a period and relapsing, may also affect lung cancer risk. METHODS: We examined changes in smoking status and cigarettes per day among 24 613 Finnish male smokers aged 50-69 years who participated in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Longitudinal data on smoking were collected during study follow-up visits 3 times a year (approximately every 4 months) between 1985 and 1993. Incident lung cancer patients through 2012 were identified by the Finnish Cancer Registry. Risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression. RESULTS: Compared with smoking 20 cigarettes per day continuously across the intervention period, reducing an average of 5 cigarettes per day per year while smoking was associated with a 20% lower risk of lung cancer (95% CI = 0.71 to 0.90). A substantially lower risk of lung cancer was also observed when participants smoked at 50% (RR = 0.72, 95% CI = 0.57 to 0.90) and 10% (RR = 0.55, 95% CI = 0.36 to 0.83) of study visits, relative to smoked at 100% of study visits. CONCLUSIONS: Smokers may lower their risk of lung cancer by reducing smoking intensity (cigarettes per day while smoking) and the time they smoke. However, quitting smoking completely is the most effective way for smokers to reduce their risk of lung cancer.