Effect of different nutrients on blood glucose, inflammatory response and oxidative stress in gestational diabetes mellitus: a network meta-analysis.
Study Goal
The researchers aimed to evaluate the effectiveness of Vitamin A, in combination with other nutrients, in improving blood glucose, reducing inflammation, and oxidative stress in patients with gestational diabetes.
Results Summary
The study found that Vitamin A combined with Vitamin D and Vitamin E ranked first in lowering fasting and postprandial blood glucose levels. However, the reliability of conclusions was noted to require further validation due to high uncertainty and variability in study quality.
Population
Patients with gestational diabetes (total of 1362 patients across 18 studies).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
different nutrients | decrease | blood glucose | patients with gestational diabetes | P < 0.05 | had a significant effect on improving | #1 |
different nutrients | decrease | inflammation levels | patients with gestational diabetes | P < 0.05 | had a significant effect on reducing | #2 |
different nutrients | decrease | oxidative stress | patients with gestational diabetes | P < 0.05 | had a significant effect on reducing | #3 |
vitamin A + vitamin D + vitamin E | decrease | fasting blood glucose | patients with gestational diabetes | SMD = 41.30, 95 % CI (2.07, 825.60) | ranked first in lowering | #4 |
vitamin A + vitamin D + vitamin E | decrease | postprandial 2-h blood glucose | patients with gestational diabetes | SMD = 15.19, 95 % CI (4.16, 55.53) | ranked first in lowering | #5 |
vitamin D | decrease | insulin resistance index | patients with gestational diabetes | SMD = 5.12, 95 % CI (0.76, 34.54) | the first highest probability ranking is | #6 |
VE | decrease | high-sensitivity C-reactive protein level | patients with gestational diabetes | SMD = 2.58, 95 % CI (1.87,3.55) | the first in probability ranking is | #7 |
Mg + Zn + Ca + VD | decrease | TNF-α | patients with gestational diabetes | SMD = 1.90, 95% CI (0.40, 9.08) | ranked first in reducing | #8 |
Mg + Zn + Ca + VD | decrease | IL-6 | patients with gestational diabetes | SMD = 1.83, 95 % CI (0.37, 9.12) | ranked first in reducing | #9 |
VB1 | decrease | malondialdehyde levels | patients with gestational diabetes | SMD = 4.99, 95 % CI (1.85, 13.46) | the first ranked probability is | #10 |
Ca + VD | increase | total antioxidant capacity | patients with gestational diabetes | SMD = 0.66,95 % CI (0.38, 1.15) | ranked first in reducing | #11 |
Ca + VD | increase | glutathione | patients with gestational diabetes | SMD = 1.39, 95 % CI (0.43, 4.56) | ranked first in reducing | #12 |
nutritional interventions | decrease | blood glucose | patients with gestational diabetes | - | have significant effects on improving | #13 |
nutritional interventions | decrease | inflammatory levels | patients with gestational diabetes | - | have significant effects on improving | #14 |
nutritional interventions | decrease | oxidative stress | patients with gestational diabetes | - | have significant effects on improving | #15 |
We searched PubMed, Web of Science, Embase, The Cochrane Library, China Biomedical Literature Database and other databases from inception to June 2023. The included studies were randomised controlled trials (RCT). The studies were screened by four authors, divided into two independent pairs. A total of eighteen studies were included, including 1362 patients, involving twelve intervention measures. The different nutrients had a significant effect on improving blood glucose, reducing inflammation levels and reducing oxidative stress compared with placebo (P < 0.05). Cumulative probability ranking showed that vitamin A + vitamin D + vitamin E ranked first in lowering fasting blood glucose (standardised mean difference (SMD) = 41.30, 95 % CI (2.07, 825.60)) and postprandial 2-h blood glucose (SMD = 15.19, 95 % CI (4.16, 55.53)). In terms of insulin resistance index, the first highest probability ranking is vitamin D (SMD = 5.12, 95 % CI (0.76, 34.54)). In terms of reducing the high-sensitivity C-reactive protein level, the first in probability ranking is VE (SMD = 2.58, 95 % CI (1.87,3.55)). The results of cumulative probability ranking showed that Mg + Zn + Ca + VD ranked first in reducing TNF-α (SMD = 1.90, 95% CI (0.40, 9.08)) and IL-6 (SMD = 1.83, 95 % CI (0.37, 9.12)). In terms of reducing malondialdehyde levels, the first ranked probability is VB1 (SMD = 4.99, 95 % CI (1.85, 13.46)). Cumulative probability ranking results showed that Ca + VD ranked first in reducing total antioxidant capacity (SMD = 0.66,95 % CI (0.38, 1.15)) and glutathione (SMD = 1.39, 95 % CI (0.43, 4.56)). In conclusion, nutritional interventions have significant effects on improving blood glucose, inflammatory levels and oxidative stress in patients with gestational diabetes. Due to the high uncertainty in the results and differences in the number and quality of studies included, the reliability of the conclusions still needs to be validated by conducting large-sample, high-quality RCT studies.