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Effect of different nutrients on blood glucose, inflammatory response and oxidative stress in gestational diabetes mellitus: a network meta-analysis.

The British journal of nutrition
January 1, 1970
Lingling Yu et al. (5 authors)
Journal ArticleResearch Support, Non-U.S. Gov'tNetwork Meta-AnalysisHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the effectiveness of Vitamin A, in combination with other nutrients, in improving blood glucose, reducing inflammation, and oxidative stress in patients with gestational diabetes.

Results Summary

The study found that Vitamin A combined with Vitamin D and Vitamin E ranked first in lowering fasting and postprandial blood glucose levels. However, the reliability of conclusions was noted to require further validation due to high uncertainty and variability in study quality.

Population

Patients with gestational diabetes (total of 1362 patients across 18 studies).

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (15)
InterventionDirectionEndpointPopulationDosageImpactClaim #
different nutrients
decrease
blood glucose
patients with gestational diabetes
P < 0.05
had a significant effect on improving
#1
different nutrients
decrease
inflammation levels
patients with gestational diabetes
P < 0.05
had a significant effect on reducing
#2
different nutrients
decrease
oxidative stress
patients with gestational diabetes
P < 0.05
had a significant effect on reducing
#3
vitamin A + vitamin D + vitamin E
decrease
fasting blood glucose
patients with gestational diabetes
SMD = 41.30, 95 % CI (2.07, 825.60)
ranked first in lowering
#4
vitamin A + vitamin D + vitamin E
decrease
postprandial 2-h blood glucose
patients with gestational diabetes
SMD = 15.19, 95 % CI (4.16, 55.53)
ranked first in lowering
#5
vitamin D
decrease
insulin resistance index
patients with gestational diabetes
SMD = 5.12, 95 % CI (0.76, 34.54)
the first highest probability ranking is
#6
VE
decrease
high-sensitivity C-reactive protein level
patients with gestational diabetes
SMD = 2.58, 95 % CI (1.87,3.55)
the first in probability ranking is
#7
Mg + Zn + Ca + VD
decrease
TNF-α
patients with gestational diabetes
SMD = 1.90, 95% CI (0.40, 9.08)
ranked first in reducing
#8
Mg + Zn + Ca + VD
decrease
IL-6
patients with gestational diabetes
SMD = 1.83, 95 % CI (0.37, 9.12)
ranked first in reducing
#9
VB1
decrease
malondialdehyde levels
patients with gestational diabetes
SMD = 4.99, 95 % CI (1.85, 13.46)
the first ranked probability is
#10
Ca + VD
increase
total antioxidant capacity
patients with gestational diabetes
SMD = 0.66,95 % CI (0.38, 1.15)
ranked first in reducing
#11
Ca + VD
increase
glutathione
patients with gestational diabetes
SMD = 1.39, 95 % CI (0.43, 4.56)
ranked first in reducing
#12
nutritional interventions
decrease
blood glucose
patients with gestational diabetes
-
have significant effects on improving
#13
nutritional interventions
decrease
inflammatory levels
patients with gestational diabetes
-
have significant effects on improving
#14
nutritional interventions
decrease
oxidative stress
patients with gestational diabetes
-
have significant effects on improving
#15
Abstract

We searched PubMed, Web of Science, Embase, The Cochrane Library, China Biomedical Literature Database and other databases from inception to June 2023. The included studies were randomised controlled trials (RCT). The studies were screened by four authors, divided into two independent pairs. A total of eighteen studies were included, including 1362 patients, involving twelve intervention measures. The different nutrients had a significant effect on improving blood glucose, reducing inflammation levels and reducing oxidative stress compared with placebo (P < 0.05). Cumulative probability ranking showed that vitamin A + vitamin D + vitamin E ranked first in lowering fasting blood glucose (standardised mean difference (SMD) = 41.30, 95 % CI (2.07, 825.60)) and postprandial 2-h blood glucose (SMD = 15.19, 95 % CI (4.16, 55.53)). In terms of insulin resistance index, the first highest probability ranking is vitamin D (SMD = 5.12, 95 % CI (0.76, 34.54)). In terms of reducing the high-sensitivity C-reactive protein level, the first in probability ranking is VE (SMD = 2.58, 95 % CI (1.87,3.55)). The results of cumulative probability ranking showed that Mg + Zn + Ca + VD ranked first in reducing TNF-α (SMD = 1.90, 95% CI (0.40, 9.08)) and IL-6 (SMD = 1.83, 95 % CI (0.37, 9.12)). In terms of reducing malondialdehyde levels, the first ranked probability is VB1 (SMD = 4.99, 95 % CI (1.85, 13.46)). Cumulative probability ranking results showed that Ca + VD ranked first in reducing total antioxidant capacity (SMD = 0.66,95 % CI (0.38, 1.15)) and glutathione (SMD = 1.39, 95 % CI (0.43, 4.56)). In conclusion, nutritional interventions have significant effects on improving blood glucose, inflammatory levels and oxidative stress in patients with gestational diabetes. Due to the high uncertainty in the results and differences in the number and quality of studies included, the reliability of the conclusions still needs to be validated by conducting large-sample, high-quality RCT studies.

Medical Subject Headings (MeSH)
FemaleHumansPregnancyBlood GlucoseC-Reactive ProteinDiabetes, GestationalInflammationInsulin ResistanceNutrientsOxidative StressRandomized Controlled Trials as TopicVitamin D
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality75/10
Citation Metrics
Total Citations3
Citations/Year3.0
Research Impact Scores
APT Score0.75
Weight Score1.46
Normalized Score0.69
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