High-dose vitamin D
Study Goal
The researchers aimed to investigate the effect of vitamin D on immune system markers and respiratory tract infections in infertile men.
Results Summary
The study found an inverse association between vitamin D status and total leucocyte concentrations, suggesting potential immune-modulating effects. High-dose vitamin D supplementation was associated with reduced leucocyte counts, indicating possible anti-inflammatory benefits.
Population
Infertile men
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D | neutral | immune system | - | - | influence | #1 |
vitamin D | decrease | total leucocyte concentrations | infertile men | 7.0 vs. 6.0 vs. 6.0 vs. 5.5 (10^9/L) | inverse association | #2 |
vitamin D | decrease | neutrophil concentrations | infertile men | 4.0 vs. 3.5 vs. 3.5 vs. 3.0 (10^9/L) | inverse association | #3 |
vitamin D | decrease | monocyte concentrations | infertile men | 0.5 vs. 0.5 vs. 0.4 vs. 0.4 (10^9/L) | inverse association | #4 |
vitamin D | decrease | lymphocyte concentrations | infertile men | 1.8 vs. 1.6 vs. 1.6 vs. 1.5 (10^9/L) | inverse association | #5 |
high-dose vitamin D | decrease | total leucocyte concentrations | infertile men | - | reduced | #6 |
high-dose vitamin D | decrease | neutrophil concentrations | infertile men | - | reduced | #7 |
high-dose vitamin D | decrease | monocyte concentrations | infertile men | - | reduced | #8 |
high-dose vitamin D | decrease | lymphocyte concentrations | infertile men | - | reduced | #9 |
BACKGROUND: Vitamin D has been suggested to influence the immune system, and vitamin D metabolites and the vitamin D receptor (VDR) are generated and expressed in white blood cells (WBC). Moreover, vitamin D status has been associated with incidence and prognosis of some respiratory tract infections (RTI). Therefore, we investigated the effect of vitamin D METHODS: A double-blinded, randomized, placebo-controlled clinical trial of 307 infertile men with multiple secondary immunological endpoints. The vitamin D RESULTS: At baseline, stratification into clinically relevant groups of vitamin D status (< 25; 25-50; 50-75; >75 nmol/L), showed an inverse association with total leucocyte concentrations (7.0 vs. 6.0 vs. 6.0 vs. 5.5 (10 CONCLUSIONS: High-dose vitamin D TRIAL REGISTRATION: NCT01304927 (ClinicalTrials.gov). Registered February 20, 2011.