Improvements in markers of inflammation and coagulation potential following a 5-day high-fat diet rich in cottonseed oil vs. Olive oil in healthy males.
Study Goal
The researchers aimed to compare the effects of cottonseed oil (CSO) and olive oil (OO) on markers of inflammation and coagulation potential in healthy adult males.
Results Summary
The study found that CSO-enriched diets reduced TNF-α and Tissue Factor (TF) more effectively than OO-enriched diets, but there were no differences in IL-6, CRP, or PAI-1 between the two diets.
Population
Healthy, normal-weight adult males aged 21.7 ± 2.58 years.
Effective Dosage
44% of total energy from oil (either CSO or OO).
Duration
5-day outpatient, controlled feeding intervention.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Cottonseed oil (CSO)-enriched diets | decrease | Tumor Necrosis Factor Alpha (TNF-α) | healthy adult males | -0.12 ± 0.02 pg/ml | reduced | #1 |
Cottonseed oil (CSO)-enriched diets | decrease | Tissue Factor (TF) | healthy adult males | -0.59 ± 0.68 pg/ml | reduced | #2 |
Cottonseed oil (CSO)-enriched diets | no change | Interleukin-6 (IL-6) | healthy adult males | - | no differences | #3 |
Cottonseed oil (CSO)-enriched diets | no change | C-Reactive Protein (CRP) | healthy adult males | - | no differences | #4 |
Cottonseed oil (CSO)-enriched diets | no change | Plasminogen Activator Inhibitor-1 (PAI-1) | healthy adult males | - | no differences | #5 |
A 5-day, CSO-enriched diet | decrease | inflammation and coagulation potential | healthy male population | - | may be sufficient to reduce | #6 |
UNLABELLED: Low-grade inflammation is believed to be a risk factor for chronic diseases and is nutritionally responsive. Cottonseed oil (CSO), which is rich in n-6 polyunsaturated fats, has been shown to lower cholesterol and other chronic disease risk factors. The purpose of this secondary analysis was to determine the comparative responses of markers of inflammation and coagulation potential of healthy adult males consuming diets rich in CSO vs. olive oil (OO). METHODS: Fifteen normal-weight males, ages 21.7 ± 2.58y, completed a randomized crossover trial. Each intervention consisted of a 3-day lead-in diet and a 5-day outpatient, controlled feeding intervention (CSO or OO). There was a 2 to 4-week washout period between interventions. The 5-day intervention diets were 35 % carbohydrate, 15 % protein, and 50 % fat, enriched with either CSO or OO (44 % of total energy from oil). At pre- and post- diet intervention visits, a fasting blood draw was collected for analysis of markers of inflammation (Tumor Necrosis Factor Alpha (TNF-α), Interleukin-6 (IL-6), C-Reactive Protein (CRP)) and coagulation potential (Tissue Factor (TF), Plasminogen Activator Inhibitor-1 (PAI-1)). RESULTS: The CSO-enriched diets reduced TNF-α (CSO: -0.12 ± 0.02 pg/ml, OO: -0.01 ± 0.05 pg/ml; p < 0.01) and TF (CSO: -0.59 ± 0.68 pg/ml, OO: 1.13 ± 0.83 pg/ml; p = 0.02) compared to OO diets. There were no differences in IL-6, CRP, or PAI-1 between diets. CONCLUSION: A 5-day, CSO-enriched diet may be sufficient to reduce inflammation and coagulation potential compared to OO-enriched diets in a healthy male population which could have implications in chronic disease prevention.