Effect of diet low in advanced glycation end products on appetite, body composition, and brown adipose tissue markers in patients with coronary artery disease treated with angioplasty: A randomized controlled trial.
Study Goal
The researchers aimed to determine whether restricting dietary advanced glycation end products (AGEs) could affect appetite, body composition, anthropometric indices, and BAT-derived markers in CAD patients treated with angioplasty.
Results Summary
A low-AGEs diet significantly reduced weight, fat mass index (FMI), abdominal volume index (AVI), and body adiposity index (BAI), as well as decreased subjective hunger and prospective food intake in stented CAD patients. No significant differences were observed in measured biochemical markers between the groups.
Population
Forty-two stented CAD patients.
Effective Dosage
Not specified.
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-AGEs diet | decrease | weight | stented CAD patients | - | could cause a significant reduction | #1 |
low-AGEs diet | decrease | FMI | stented CAD patients | - | could cause a significant reduction | #2 |
low-AGEs diet | decrease | AVI | stented CAD patients | - | could cause a significant reduction | #3 |
low-AGEs diet | decrease | BAI | stented CAD patients | - | could cause a significant reduction | #4 |
low-AGEs diet | decrease | sense of hunger | stented CAD patients | - | indicated a significant decrease | #5 |
low-AGEs diet | decrease | prospective food intake | stented CAD patients | - | indicated a significant decrease | #6 |
low-AGEs diet | no change | measured biochemical markers | stented CAD patients | no significant difference | No significant difference was seen | #7 |
low-AGEs diet | decrease | appetite | stented CAD patients | - | could decrease | #8 |
low-AGEs diet | decrease | weight | stented CAD patients | - | could decrease | #9 |
low-AGEs diet | decrease | anthropometric indices | stented CAD patients | - | could decrease | #10 |
BACKGROUND: Recent changes in dietary habits have resulted in increased intake of advanced glycation end products (AGEs), which are known to have a predominant contribution to the pathogenesis and complications of coronary artery disease (CAD). AGEs are also thought to induce weight gain by affecting appetite, energy expenditure, and brown adipose tissue (BAT). Here, we investigated whether the restriction of dietary AGEs could affect appetite, body composition, anthropometric indices, and BAT-derived markers in CAD patients treated with angioplasty. MATERIALS AND METHODS: Forty-two stented CAD patients were randomly allocated into two groups that received either a low-AGEs or a control diet for 12 weeks. At baseline and postintervention, fasting blood samples were analyzed for total AGEs, nesfatin-1, and BAT-derived markers (fibroblast growth factor 21 and neuregulin 4). Subjective appetite ratings and body composition were evaluated using the Visual Analog Scale (VAS) and bioelectric impedance analysis. Anthropometric indices, including fat mass index (FMI), abdominal volume index (AVI), and body adiposity index (BAI), were calculated through the relevant formula. RESULTS: Restricting dietary AGEs for 12 weeks could cause a significant reduction in weight, FMI, AVI, and BAI (P < 0.05) compared to the comparison group. In addition, VAS data analyses indicated a significant decrease in the sense of hunger and prospective food intake (P < 0.05) in the intervention group compared to the comparison group. No significant difference was seen in the measured biochemical markers between the two groups. CONCLUSION: This study indicated that the low-AGEs diet could decrease appetite, weight, and anthropometric indices in stented CAD patients.