Ten weeks of Capsicum annuum L. extract supplementation did not change adipose tissue-derived hormones, appetite, body composition, and muscle strength when combined with resistance training in healthy untrained men: A clinical trial study.
Study Goal
The researchers aimed to determine whether chronic capsiate supplementation combined with resistance training enhances adipose tissue-derived hormones, body composition, appetite, and muscle strength compared to resistance training alone in healthy untrained men.
Results Summary
The study found that 10 weeks of resistance training increased body weight, muscle mass, and strength, but capsiate supplementation (12 mg/day) did not significantly affect adipose tissue-derived hormones, appetite, body composition, or muscle strength beyond the effects of training alone.
Population
Healthy untrained young men (age 22.0 ± 2.9).
Effective Dosage
12 mg/day, 7 days per week.
Duration
10 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
10 weeks of resistance training | increase | total body weight | healthy untrained men | - | increased | #1 |
10 weeks of resistance training | increase | muscle mass | healthy untrained men | - | increased | #2 |
10 weeks of resistance training | increase | maximum strength | healthy untrained men | - | increased | #3 |
CAP supplementation (12 mg, 7 days per week) | no change | adipose tissue-derived hormones | healthy untrained men | - | failed to change | #4 |
CAP supplementation (12 mg, 7 days per week) | no change | appetite | healthy untrained men | - | failed to change | #5 |
CAP supplementation (12 mg, 7 days per week) | no change | body composition | healthy untrained men | - | failed to change | #6 |
CAP supplementation (12 mg, 7 days per week) | no change | muscle strength | healthy untrained men | - | failed to change | #7 |
10 weeks of progressive resistance training | increase | body mass | healthy untrained men | - | significant increase | #8 |
10 weeks of progressive resistance training | increase | fat-free mass | healthy untrained men | - | significant increase | #9 |
10 weeks of progressive resistance training | increase | resting metabolic rate | healthy untrained men | - | significant increase | #10 |
10 weeks of progressive resistance training | increase | maximal strength at 45 leg press | healthy untrained men | - | significant increase | #11 |
10 weeks of progressive resistance training | increase | maximal strength at bench press | healthy untrained men | - | significant increase | #12 |
CAP supplementation (12 mg/day) combined with resistance training | no change | fat mass | healthy untrained men | - | no significant supplementation by training period interaction | #13 |
CAP supplementation (12 mg/day) combined with resistance training | no change | subjective ratings of appetite | healthy untrained men | - | no significant effect of supplementation by training period interaction | #14 |
CAP supplementation (12 mg/day) combined with resistance training | no change | energy intake | healthy untrained men | - | no significant effect of supplementation by training period interaction | #15 |
CAP supplementation (12 mg/day) combined with resistance training | no change | leptin | healthy untrained men | - | no significant effect of supplementation by training period interaction | #16 |
CAP supplementation (12 mg/day) combined with resistance training | no change | adiponectin | healthy untrained men | - | no significant effect of supplementation by training period interaction | #17 |
Capsiate (CAP) is a nonpungent capsaicin analog (Capsicum annuum L. extract) that has been studied as a potential antiobesity agent. However, the interaction between chronic CAP supplementation and resistance training is not clear. The purpose of this study was to examine the changes in adipose tissue-derived hormones, body composition, appetite, and muscle strength after 10 weeks of resistance training, combined with chronic CAP supplementation in healthy untrained men. We hypothesized that CAP could induce higher benefits when combined with resistance training after 10 weeks of intervention compared to resistance training alone. Twenty-four young men (age, 22.0 ± 2.9) were randomized to either capsiate supplementation (CAP = 12 mg/day) or placebo (PL), and both groups were assigned to resistance training. Body composition, leptin and adiponectin concentrations, subjective ratings of appetite, energy intake, and exercise performance were assessed at before and after 10 weeks of progressive resistance training. There was a significant increase in body mass (P < .001), fat-free mass (CAP: 58.0 ± 7.1 vs. post, 59.7 ± 7.1 kg; PL: pre, 58.4 ± 7.3 vs. post, 59.8 ± 7.1 kg; P < .001), resting metabolic rate (CAP: pre, 1782.9 ± 160.6 vs. post, 1796.3 ± 162.0 kcal; PL: pre, 1733.0 ± 148.9 vs. post, 1750.5 ± 149.8 kcal; P < .001), maximal strength at 45 leg press (P < .001) and bench press (P < .001) in both groups, but no significant (P > .05) supplementation by training period interaction nor fat mass was observed. For subjective ratings of appetite, energy intake, leptin, and adiponectin, no significant effect of supplementation by training period interaction was observed (P > .05). In conclusion, 10 weeks of resistance training increased total body weight, muscle mass, and maximum strength in healthy untrained men; however, CAP supplementation (12 mg, 7 days per week) failed to change adipose tissue-derived hormones, appetite, body composition and muscle strength in this population. Registered under Brazilian Registry of Clinical Trials (RBR-8cz9kfq).