The efficacy of magnesium supplementation for gestational diabetes: A meta-analysis of randomized controlled trials.
Study Goal
The researchers aimed to determine the efficacy of magnesium supplementation for glycemic control and pregnancy outcomes in women with gestational diabetes.
Results Summary
Magnesium supplementation significantly decreased FPG and HOMA-IR but had no significant impact on serum insulin, preterm delivery, macrosomia, or BMI change. The study concluded that magnesium may be effective for gestational diabetes without insulin treatment.
Population
Women with gestational diabetes
Effective Dosage
Not available
Duration
Not available
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
magnesium supplementation | decrease | FPG | women with gestational diabetes | MD = -7.33 mg/dL | significantly decrease | #1 |
magnesium supplementation | decrease | HOMA-IR | women with gestational diabetes | MD = -0.99 | significantly decrease | #2 |
magnesium supplementation | no change | serum insulin | women with gestational diabetes | MD = -4.17 μIU/mL | no obvious impact | #3 |
magnesium supplementation | no change | preterm delivery | women with gestational diabetes | OR = 0.42 | no obvious impact | #4 |
magnesium supplementation | no change | macrosomia | women with gestational diabetes | OR = 0.34 | no obvious impact | #5 |
magnesium supplementation | no change | BMI change | women with gestational diabetes | MD = -0.01 kg/m | no obvious impact | #6 |
magnesium supplementation | neutral | gestational diabetes without taking insulin treatment | women with gestational diabetes | - | may be effective for the treatment | #7 |
BACKGROUND: The efficacy of magnesium supplementation is unclear for the treatment of gestational diabetes. This meta-analysis aimed to study the efficacy of magnesium supplementation for glycemic control and pregnant outcomes in women with gestational diabetes. METHODS: Several databases including PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases have been systematically searched up to July 2023, and we included randomized controlled trials (RCTs) assessing the efficacy of magnesium supplementation for gestational diabetes. The meta-analysis was performed using the random-effect model or fixed-effect model based on the heterogeneity. RESULTS: Five RCTs and 266 patients were included in the meta-analysis. Overall, compared with control intervention for gestational diabetes, magnesium supplementation was able to significantly decrease FPG (MD = -7.33 mg/dL; 95 % CI = -7.64 to -7.02 mg/dL; P < 0.00001) and HOMA-IR (MD = -0.99; 95 % CI = -1.76 to -0.22; P = 0.01), but resulted in no obvious impact on serum insulin (MD = -4.17 μIU/mL; 95 % CI = -8.49 to 0.14 μIU/mL; P = 0.06), preterm delivery (OR = 0.42; 95 % CI = 0.06 to 2.95; P = 0.38), macrosomia (OR = 0.34; 95 % CI = 0.08 to 1.35; P = 0.13) or BMI change (MD = -0.01 kg/m CONCLUSIONS: Magnesium supplementation may be effective for the treatment of gestational diabetes without taking insulin treatment.