Melatonin supplementation does not alter vascular function or oxidative stress in healthy normotensive adults on a high sodium diet.
Study Goal
The researchers aimed to determine whether melatonin supplementation improves vascular function and reduces reactive oxygen species (ROS) during a 10-day high sodium diet (HSD).
Results Summary
The study hypothesized that melatonin would improve vascular function and decrease ROS levels compared to HSD alone, but the abstract does not provide specific results on these outcomes.
Population
27 participants (13 male, 14 female), aged 26.7 ± 2.9 years, with a BMI of 23.6 ± 2.0 kg/m².
Effective Dosage
Not specified
Duration
10 days
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
High sodium diets (HSD) | increase | vascular dysfunction | - | - | can cause | #1 |
High sodium diets (HSD) | increase | reactive oxygen species (ROS) | - | - | increases | #2 |
Melatonin | decrease | ROS | healthy and clinical populations | - | reduces | #3 |
Melatonin | increase | vascular function | - | - | may improve | #4 |
melatonin supplementation during a HSD | increase | vascular function | - | - | would improve | #5 |
melatonin supplementation during a HSD | decrease | ROS levels | - | - | decrease | #6 |
High sodium diets (HSD) can cause vascular dysfunction, in part due to increases in reactive oxygen species (ROS). Melatonin reduces ROS in healthy and clinical populations and may improve vascular function. The purpose was to determine the effect of melatonin supplementation on vascular function and ROS during 10 days of a HSD. We hypothesized that melatonin supplementation during a HSD would improve vascular function and decrease ROS levels compared to HSD alone. Twenty-seven participants (13 M/14 W, 26.7 ± 2.9 years, BMI: 23.6 ± 2.0 kg/m