The effects of 12 weeks resistance training and vitamin D administration on neuromuscular joint, muscle strength and power in postmenopausal women.
Study Goal
The researchers aimed to determine whether vitamin D supplementation, alone or combined with resistance training, improves muscle strength and neuromuscular biomarkers (CAF and NT-3) in postmenopausal women.
Results Summary
Vitamin D supplementation did not significantly improve muscle strength or power compared to placebo, nor did it affect CAF or NT-3 levels. Resistance training alone or combined with vitamin D increased muscle strength, but vitamin D provided no additional benefit.
Population
Healthy postmenopausal women (mean age 55.84 ± 4.70 years, BMI 29.61 ± 4.26 kg/m²).
Effective Dosage
50,000 IU cholecalciferol every two weeks.
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Resistance training + vitamin D | no change | Circulating levels of CAF and NT-3 | postmenopausal women | no significant change | did not significantly change | #1 |
Resistance training + placebo | no change | Circulating levels of CAF and NT-3 | postmenopausal women | no significant change | did not significantly change | #2 |
Vitamin D supplementation | no change | Circulating levels of CAF and NT-3 | postmenopausal women | no significant change | did not significantly change | #3 |
Placebo | no change | Circulating levels of CAF and NT-3 | postmenopausal women | no significant change | did not significantly change | #4 |
Resistance training + vitamin D | increase | upper and lower body muscle strength and power | postmenopausal women | - | significant increases | #5 |
Resistance training + placebo | increase | upper and lower body muscle strength and power | postmenopausal women | - | significant increases | #6 |
Vitamin D supplementation | no change | upper and lower body muscle strength and power | postmenopausal women | - | not | #7 |
Placebo | no change | upper and lower body muscle strength and power | postmenopausal women | - | not | #8 |
12-week of RT interventions | increase | muscle strength and power | postmenopausal women | - | resulted in significant increases | #9 |
VitD supplementation | no change | muscle function | postmenopausal women | - | did not result in any additional benefits | #10 |
BACKGROUND: This study aimed to examine the effects of 12 weeks of resistance training (RT) and vitamin D (VitD) supplementation on muscle strength and C-terminal agrin fragment (CAF) and Neurotrophin-3 (NT-3) concentrations as potential biomarkers in postmenopausal women. METHODS: This was a randomized double-blind placebo-controlled study. Forty-four healthy postmenopausal women (55.84 ± 4.70 years and 29.61 ± 4.26 kg/m2) were randomly assigned into four groups: (1) Resistance training + placebo (RT + PLA), (2) Vitamin D supplementation (VitD), (3) Resistance training + vitamin D (RT + VitD), and (4) Placebo (PLA). VitD was supplemented as an oral capsule containing 50000 IU of cholecalciferol every two weeks. RT involved leg press, chest press, leg extension, leg curl, and shoulder press exercises, performed with 3-4 sets at 70-85 % of 1RM, three times a week. RESULTS: Circulating levels of CAF and NT-3 did not significantly change following the intervention period in the study groups (p > 0.05). There were significant increases in upper and lower body muscle strength and power for RT + VitD and RT + PLA ( < 0.05), but not for VitD or PLA (p > 0.05). The muscle function gains for RT + VitD and RT + PLA were higher than those for VitD and PLA but did not differ between them. CONCLUSION: 12-week of RT interventions resulted in significant increases in muscle strength and power in postmenopausal women. However, VitD supplementation did not result in any additional benefits. The positive changes in muscle function promoted by RT do not seem to be associated with changes in the neuromuscular joint via the CAF or NT-3 as potential biomarkers.