Effects of an Unripe Avocado Extract on Glycaemic Control in Individuals with Obesity: A Double-Blinded, Parallel, Randomised Clinical Trial.
Study Goal
To evaluate the effects of a diet supplement made from unripe avocado on glucose tolerance and cardiometabolic risk factors in nondiabetic adults with obesity.
Results Summary
Daily consumption of unripe avocado extract did not significantly alter glucose tolerance or insulin sensitivity overall, but showed preliminary benefits in insulin AUC for a subgroup with elevated baseline postprandial insulin levels.
Population
Nondiabetic adults with obesity (60 participants, 47 female, age 48 ± 13 years, BMI 34.0 ± 2.6 kg/m²).
Effective Dosage
Not specified in the abstract.
Duration
Not specified in the abstract.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
diet supplement made from unripe avocado | no change | glucose AUC | free-living nondiabetic adults with obesity | - | no between-group differences | #1 |
diet supplement made from unripe avocado | no change | insulin AUC | free-living nondiabetic adults with obesity | - | no between-group differences | #2 |
diet supplement made from unripe avocado | no change | fasting glucose | free-living nondiabetic adults with obesity | - | no between-group differences | #3 |
diet supplement made from unripe avocado | no change | fasting insulin | free-living nondiabetic adults with obesity | - | no between-group differences | #4 |
diet supplement made from unripe avocado | no change | HOMA-IR | free-living nondiabetic adults with obesity | - | no between-group differences | #5 |
diet supplement made from unripe avocado | no change | body weight | free-living nondiabetic adults with obesity | - | no between-group differences | #6 |
diet supplement made from unripe avocado | no change | body fat | free-living nondiabetic adults with obesity | - | no between-group differences | #7 |
diet supplement made from unripe avocado | no change | blood pressure | free-living nondiabetic adults with obesity | - | no between-group differences | #8 |
diet supplement made from unripe avocado | no change | blood lipids | free-living nondiabetic adults with obesity | - | no between-group differences | #9 |
daily consumption of unripe avocado extract enriched in MH | no change | glucose tolerance | nondiabetic adults with obesity | - | did not alter | #10 |
daily consumption of unripe avocado extract enriched in MH | no change | insulin sensitivity | nondiabetic adults with obesity | - | did not alter | #11 |
daily consumption of unripe avocado extract enriched in MH | decrease | insulin AUC | subgroup of participants with elevated baseline postprandial insulin levels | - | provided preliminary evidence for a benefit | #12 |
BACKGROUND: Unripe avocados ( OBJECTIVES: To evaluate the effects of a diet supplement made from unripe avocado on glucose tolerance, and cardiometabolic risk factors in free-living nondiabetic adults with obesity. METHODS: In a double-blinded, randomised controlled trial, 60 adults (female n = 47, age 48 ± 13 years, BMI 34.0 ± 2.6 kg/m RESULTS: There were no between-group differences in glucose AUC ( CONCLUSIONS: Daily consumption of unripe avocado extract enriched in MH did not alter glucose tolerance or insulin sensitivity in nondiabetic adults with obesity, but the data provided preliminary evidence for a benefit in insulin AUC in a subgroup of participants with elevated baseline postprandial insulin levels.