Modulatory Properties of Vitamin D in Type 2 Diabetic Patients: A Focus on Inflammation and Dyslipidemia.
Study Goal
The researchers aimed to determine the effect of vitamin D supplementation on inflammation and dyslipidemia in patients with type 2 diabetes (T2D).
Results Summary
The study found that vitamin D supplementation significantly reduced tumor necrosis factor-alpha (TNF-α) levels, suggesting potential benefits in ameliorating inflammation and dyslipidemia in T2D patients.
Population
Patients with type 2 diabetes (T2D).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation | decrease | tumor necrosis factor-alpha (TNF-α) | T2D patients | SMD = (-0.51, 95%CI (-0.93, -0.09) | significant reduction | #1 |
vitamin D supplementation | decrease | total cholesterol | T2D patients | SMD = (-0.35, 95%CI (-0.66, -0.04) | significant reduction | #2 |
vitamin D supplementation | decrease | low-density lipoprotein (LDL) | T2D patients | SMD = (-0.40, 95%CI (-0.70, -0.10) | significant reduction | #3 |
vitamin D supplementation | no change | high-density lipoprotein (HDL) | T2D patients | SMD = (-0.01, 95%CI (-0.21, 0.19) | no significant effect | #4 |
vitamin D supplementation | no change | triglycerides | T2D patients | SMD = (-0.15, 95%CI (-0.35, 0.05) | no significant effect | #5 |
vitamin D supplementation | decrease | inflammation and dyslipidemia | T2D patients | - | may be beneficial in ameliorating | #6 |
BACKGROUND: Evidence from preclinical studies has found a correlation between the development of type 2 diabetes (T2D) and vitamin D deficiency. However, evidence from randomized controlled trials (RCTs) revealed inconclusive results on vitamin D supplementation. We explored the effect of vitamin D on inflammation and dyslipidemia in T2D. METHODS: We comprehensively searched for RCTs evaluating the effect of vitamin D in T2D on PubMed. Data were analyzed using Review Manager 5.3 and reports, such as standardized mean difference (SMD) and 95% confidence intervals (CI) at a 5% significant level using a random effect model. RESULTS: This study revealed a significant reduction in tumor necrosis factor-alpha (TNF-α) SMD = (-0.51, 95%CI (-0.93, -0.09); CONCLUSIONS: These findings suggest that vitamin D supplementation may be beneficial in ameliorating inflammation and dyslipidemia in T2D patients.