A systematic literature review and meta-analysis of the effectiveness of vitamin D supplementation for patients with Duchenne muscular dystrophy.
Study Goal
The researchers aimed to evaluate the effectiveness of vitamin D supplementation in maintaining or restoring vitamin D levels in individuals with Duchenne muscular dystrophy.
Results Summary
The study found that current dosing regimens prevent severe deficiency but are ineffective at maintaining sufficient vitamin D levels in the Duchenne population, with at least 20% remaining deficient despite high daily supplementation (>1000 IU). No significant association between dose and serum vitamin D levels was observed.
Population
Individuals with Duchenne muscular dystrophy
Effective Dosage
>1000 International Units (IU) daily
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
current dosing regimens of vitamin D supplementation | decrease | severe vitamin D deficiency | the Duchenne population | - | are preventing | #1 |
current dosing regimens of vitamin D supplementation | no change | sufficient vitamin D levels | the Duchenne population | - | are not effective at maintaining | #2 |
high levels of daily vitamin D supplementation (>1000 International Units) | no change | vitamin D deficient | at least 20% of people with Duchenne | at least 20% | remain | #3 |
vitamin D supplementation dose | no change | serum vitamin D levels | the Duchenne population | no significant association | No significant association was found between | #4 |
We conducted a systematic literature review and meta-analysis on the effectiveness of vitamin D supplementation in maintaining or restoring vitamin D levels in Duchenne muscular dystrophy. Due to a lack of randomised controlled trials, cross-sectional and retrospective and prospective cohort studies were taken as the best available evidence. Inclusion criteria included reporting mean serum vitamin D levels in a supplement-taking group. After screening 102 records; 13 were included in a narrative synthesis and eight of these in a meta-analysis. We show that current dosing regimens are preventing severe deficiency but are not effective at maintaining sufficient vitamin D levels within the Duchenne population. Despite high levels of daily vitamin D supplementation (>1000 International Units), at least 20 % of people with Duchenne remain vitamin D deficient. No significant association between dose and serum vitamin D levels was found (r