Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.
Study Goal
The researchers aimed to determine whether oral magnesium supplementation improves insulin sensitivity in individuals with insulin-treated type 2 diabetes and low serum magnesium levels.
Results Summary
Despite a modest increase in serum magnesium concentration, oral magnesium supplementation did not improve insulin sensitivity in the studied population. The study concluded that magnesium supplementation was ineffective for this purpose in insulin-treated type 2 diabetes patients with low magnesium levels.
Population
Individuals with insulin-treated type 2 diabetes (age ≥18 years, BMI 18-40 kg/m², 50% women, 100% White, mean age 67±6 years).
Effective Dosage
15 mmol/day
Duration
6 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
oral magnesium supplementation (15 mmol/day) | no change | insulin sensitivity | people with insulin-treated type 2 diabetes and low magnesium levels | - | does not improve | #1 |
oral magnesium supplementation (15 mmol/day) | increase | serum magnesium concentration | people with insulin-treated type 2 diabetes and low magnesium levels | - | modest increase | #2 |
AIMS/HYPOTHESIS: Hypomagnesaemia has been associated with insulin resistance and an increased risk of type 2 diabetes. Whether magnesium supplementation improves insulin sensitivity in people with type 2 diabetes and a low serum magnesium level is unknown. METHODS: Using a randomised, double-blind (both participants and investigators were blinded to the participants' treatment sequences), placebo-controlled, crossover study design, we compared the effect of oral magnesium supplementation (15 mmol/day) for 6 weeks with that of matched placebo in individuals with insulin-treated type 2 diabetes (age ≥18 years, BMI 18-40 kg/m RESULTS: We recruited 14 participants (50% women, 100% White, mean ± SD age 67±6 years, BMI 31±5 kg/m CONCLUSIONS/INTERPRETATION: Despite an albeit modest increase in serum magnesium concentration, oral magnesium supplementation does not improve insulin sensitivity in people with insulin-treated type 2 diabetes and low magnesium levels. TRIAL REGISTRATION: EudraCT number 2021-001243-27. FUNDING: This study was supported by a grant from the Dutch Diabetes Research Foundation (2017-81-014).