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Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia.

Cells
January 1, 1970
Kunihiro Sakuma et al. (4 authors)
Journal ArticleReviewResearch Support, Non-U.S. Gov'tHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the effectiveness of HMB supplementation, both alone and in combination with exercise, on muscle strength and mass in sarcopenia.

Results Summary

HMB supplementation alone had no significant effect on muscle strength or mass in sarcopenia, but combining HMB with whole-body vibration stimulation showed potential effectiveness.

Population

Elderly individuals with sarcopenia (human and mammalian studies referenced).

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (7)
InterventionDirectionEndpointPopulationDosageImpactClaim #
combination of resistance training with supplements containing amino acids
decrease
sarcopenia
-
-
is the gold standard for preventing
#1
Amino acid (HMB) supplementation alone
no change
muscle strength or muscle mass
sarcopenia
no significant effect
has no significant effect on
#2
combination of HMB and exercise (whole body vibration stimulation)
neutral
-
-
-
is likely to be effective
#3
Tea catechins, soy isoflavones, and ursolic acid
decrease
sarcopenia
-
-
are interesting candidates for reducing
#4
Vitamin D supplementation
no change
sarcopenia
elderly individuals who are not vitamin D-deficient
not to improve
has been shown not to improve
#5
Myostatin inhibitory drugs
increase
muscle mass and strength
many neuromuscular diseases
less likely to be expected
increases in muscle mass and strength are less likely to be expected
#6
myostatin inhibitory antibodies
neutral
-
patients with sarcopenia
positive
Validation in patients with sarcopenia has been positive
#7
Abstract

Sarcopenia is characterized by a gradual slowing of movement due to loss of muscle mass and quality, decreased power and strength, increased risk of injury from falls, and often weakness. This review will focus on recent research trends in nutritional and pharmacological approaches to controlling sarcopenia. Because nutritional studies in humans are fairly limited, this paper includes many results from nutritional studies in mammals. The combination of resistance training with supplements containing amino acids is the gold standard for preventing sarcopenia. Amino acid (HMB) supplementation alone has no significant effect on muscle strength or muscle mass in sarcopenia, but the combination of HMB and exercise (whole body vibration stimulation) is likely to be effective. Tea catechins, soy isoflavones, and ursolic acid are interesting candidates for reducing sarcopenia, but both more detailed basic research on this treatment and clinical studies in humans are needed. Vitamin D supplementation has been shown not to improve sarcopenia in elderly individuals who are not vitamin D-deficient. Myostatin inhibitory drugs have been tried in many neuromuscular diseases, but increases in muscle mass and strength are less likely to be expected. Validation of myostatin inhibitory antibodies in patients with sarcopenia has been positive, but excessive expectations are not warranted.

Medical Subject Headings (MeSH)
AnimalsHumansAgedSarcopeniaMyostatinMuscle, SkeletalMuscle StrengthDietary SupplementsAmino AcidsMammals
Study Links
Quality Scores
SafetyNot Assessed
Efficacy40/10
Quality65/10
Citation Metrics
Total Citations13
Citations/Year6.5
Relative Citation Ratio3.10
NIH Percentile85.6%
Research Impact Scores
APT Score0.75
Weight Score0.75
Normalized Score0.49
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