Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia.
Study Goal
The researchers aimed to evaluate the effectiveness of HMB supplementation, both alone and in combination with exercise, on muscle strength and mass in sarcopenia.
Results Summary
HMB supplementation alone had no significant effect on muscle strength or mass in sarcopenia, but combining HMB with whole-body vibration stimulation showed potential effectiveness.
Population
Elderly individuals with sarcopenia (human and mammalian studies referenced).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
combination of resistance training with supplements containing amino acids | decrease | sarcopenia | - | - | is the gold standard for preventing | #1 |
Amino acid (HMB) supplementation alone | no change | muscle strength or muscle mass | sarcopenia | no significant effect | has no significant effect on | #2 |
combination of HMB and exercise (whole body vibration stimulation) | neutral | - | - | - | is likely to be effective | #3 |
Tea catechins, soy isoflavones, and ursolic acid | decrease | sarcopenia | - | - | are interesting candidates for reducing | #4 |
Vitamin D supplementation | no change | sarcopenia | elderly individuals who are not vitamin D-deficient | not to improve | has been shown not to improve | #5 |
Myostatin inhibitory drugs | increase | muscle mass and strength | many neuromuscular diseases | less likely to be expected | increases in muscle mass and strength are less likely to be expected | #6 |
myostatin inhibitory antibodies | neutral | - | patients with sarcopenia | positive | Validation in patients with sarcopenia has been positive | #7 |
Sarcopenia is characterized by a gradual slowing of movement due to loss of muscle mass and quality, decreased power and strength, increased risk of injury from falls, and often weakness. This review will focus on recent research trends in nutritional and pharmacological approaches to controlling sarcopenia. Because nutritional studies in humans are fairly limited, this paper includes many results from nutritional studies in mammals. The combination of resistance training with supplements containing amino acids is the gold standard for preventing sarcopenia. Amino acid (HMB) supplementation alone has no significant effect on muscle strength or muscle mass in sarcopenia, but the combination of HMB and exercise (whole body vibration stimulation) is likely to be effective. Tea catechins, soy isoflavones, and ursolic acid are interesting candidates for reducing sarcopenia, but both more detailed basic research on this treatment and clinical studies in humans are needed. Vitamin D supplementation has been shown not to improve sarcopenia in elderly individuals who are not vitamin D-deficient. Myostatin inhibitory drugs have been tried in many neuromuscular diseases, but increases in muscle mass and strength are less likely to be expected. Validation of myostatin inhibitory antibodies in patients with sarcopenia has been positive, but excessive expectations are not warranted.