Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca
Biochemical and biophysical research communications
January 1, 1970
Shuangshan Dong et al. (14 authors)
Journal ArticleHuman StudyMolecular Study
Extracted Claims (8)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | neutral | circadian rhythms | - | - | entrainment of suprachiasmatic nucleus-regulating circadian rhythms is mediated by | #1 |
melatonin | neutral | neuroprotective effects | - | - | has | #2 |
melatonin | neutral | mitochondrial activating effects | - | - | has | #3 |
melatonin | neutral | neurodevelopment | - | - | may affect | #4 |
melatonin | neutral | autism spectrum disorder (ASD) neuropathology | - | - | pharmacological effects on | #5 |
- | decrease | reduced neurite outgrowth | ASD-DNs (dopaminergic neurons from children with ASD) | - | had | #6 |
- | neutral | mitochondrial dysfunction | ASD-DNs (dopaminergic neurons from children with ASD) | - | had | #7 |
- | decrease | lower mitochondrial Ca | ASD-DNs (dopaminergic neurons from children with ASD) | - | had | #8 |
Abstract
Melatonin entrainment of suprachiasmatic nucleus-regulating circadian rhythms is mediated by MT1 and MT2 receptors. Melatonin also has neuroprotective and mitochondrial activating effects, suggesting it may affect neurodevelopment. We studied melatonin's pharmacological effects on autism spectrum disorder (ASD) neuropathology. Deciduous tooth-derived stem cells from children with ASD were used to model neurodevelopmental defects and differentiated into dopaminergic neurons (ASD-DNs) with or without melatonin. Without melatonin, ASD-DNs had reduced neurite outgrowth, mitochondrial dysfunction, lower mitochondrial Ca
Study Links
PubMed ID37742475
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