Effect of 23 % low-sodium salt applied to Chinese modified DASH diet on cerebrovascular function in patients with hypertension and type 2 diabetes: a pilot study.
Study Goal
The researchers aimed to investigate the effects of a low-sodium formula salt combined with a Chinese Modified DASH diet on cerebrovascular function, blood pressure, and blood glucose control in patients with hypertension and type 2 diabetes.
Results Summary
The study found that the intervention significantly improved cerebrovascular function (measured by various Doppler parameters) and reduced systolic/diastolic blood pressure, fasting/postprandial blood glucose, with increased control rates for both blood pressure and glucose.
Population
66 patients with hypertension and type 2 diabetes (59 completed the study).
Effective Dosage
Low-sodium formula salt (potassium chloride 56%, sodium chloride 23%, 5 g/day) combined with a Chinese Modified DASH diet.
Duration
8 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | Peak systolic velocity of internal cerebral artery and vertebral artery | patients with hypertension and type 2 diabetes | - | decreased significantly | #1 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | mean flow velocity of internal cerebral artery and vertebral artery | patients with hypertension and type 2 diabetes | - | decreased significantly | #2 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | end-diastolic velocity of internal cerebral artery and vertebral artery | patients with hypertension and type 2 diabetes | - | decreased significantly | #3 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | pulsatility index of internal cerebral artery and vertebral artery | patients with hypertension and type 2 diabetes | - | decreased significantly | #4 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | resistance index of internal cerebral artery and vertebral artery | patients with hypertension and type 2 diabetes | - | decreased significantly | #5 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | pulsatility index of anterior cerebral artery and middle cerebral artery | patients with hypertension and type 2 diabetes | - | decreased significantly | #6 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | resistance index of anterior cerebral artery and middle cerebral artery | patients with hypertension and type 2 diabetes | - | decreased significantly | #7 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | end-diastolic velocity of basilar artery | patients with hypertension and type 2 diabetes | - | decreased significantly | #8 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | pulsatility index of basilar artery | patients with hypertension and type 2 diabetes | - | decreased significantly | #9 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | Systolic blood pressure | patients with hypertension and type 2 diabetes | - | decreased significantly | #10 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | Diastolic blood pressure | patients with hypertension and type 2 diabetes | - | decreased significantly | #11 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | fasting blood glucose | patients with hypertension and type 2 diabetes | - | decreased significantly | #12 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | decrease | postprandial blood glucose | patients with hypertension and type 2 diabetes | - | decreased significantly | #13 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | increase | Blood pressure control rates | patients with hypertension and type 2 diabetes | - | increased significantly | #14 |
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet | increase | blood glucose control rates | patients with hypertension and type 2 diabetes | - | increased significantly | #15 |
23 % low-sodium formula combined with CM-DASH diet pattern | increase | cerebrovascular function | community patients with hypertension complicated with diabetes | - | can improve | #16 |
23 % low-sodium formula combined with CM-DASH diet pattern | increase | blood pressure and glucose control | community patients with hypertension complicated with diabetes | - | has a good short-term benefit of | #17 |
Aim: to investigate the effects of low sodium formula salt combined with the Chinese Modified Dietary Approaches to Stop Hypertension (DASH) diet on cerebrovascular function in patients with hypertension and type 2 diabetes. Methods: an eight-week single-arm trial was conducted in 66 patients with hypertension and type 2 diabetes to investigate effects of low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet on cerebrovascular function (measured by transcranial Doppler sonography), indicators of chronic diseases (blood pressure, blood glucose and blood lipids) and urinary excretion. The above indicators were performed before and after intervention. Results: fifty-nine subjects completed the study. Peak systolic velocity, mean flow velocity, end-diastolic velocity, pulsatility index and resistance index of internal cerebral artery and vertebral artery decreased significantly (p < 0.05); pulsatility index and resistance index of anterior cerebral artery and middle cerebral artery decreased significantly (p < 0.05); and end-diastolic velocity and pulsatility index of basilar artery decreased significantly (p < 0.05). Systolic blood pressure, diastolic blood pressure, fasting blood glucose and postprandial blood glucose decreased significantly (p < 0.001; p < 0.001; p < 0.001; p < 0.001). Blood pressure and blood glucose control rates increased significantly (p < 0.001). Conclusions: based on the study, 23 % low-sodium formula combined with CM-DASH diet pattern can improve cerebrovascular function in community patients with hypertension complicated with diabetes and has a good short-term benefit of blood pressure and glucose control.