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Effect of 23 % low-sodium salt applied to Chinese modified DASH diet on cerebrovascular function in patients with hypertension and type 2 diabetes: a pilot study.

Nutricion hospitalaria
October 6, 2023
Yi Wu et al. (10 authors)
Journal ArticleHuman Study
Study Details

Study Goal

The researchers aimed to investigate the effects of a low-sodium formula salt combined with a Chinese Modified DASH diet on cerebrovascular function, blood pressure, and blood glucose control in patients with hypertension and type 2 diabetes.

Results Summary

The study found that the intervention significantly improved cerebrovascular function (measured by various Doppler parameters) and reduced systolic/diastolic blood pressure, fasting/postprandial blood glucose, with increased control rates for both blood pressure and glucose.

Population

66 patients with hypertension and type 2 diabetes (59 completed the study).

Effective Dosage

Low-sodium formula salt (potassium chloride 56%, sodium chloride 23%, 5 g/day) combined with a Chinese Modified DASH diet.

Duration

8 weeks

Interactions

None mentioned

Extracted Claims (17)
InterventionDirectionEndpointPopulationDosageImpactClaim #
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
Peak systolic velocity of internal cerebral artery and vertebral artery
patients with hypertension and type 2 diabetes
-
decreased significantly
#1
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
mean flow velocity of internal cerebral artery and vertebral artery
patients with hypertension and type 2 diabetes
-
decreased significantly
#2
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
end-diastolic velocity of internal cerebral artery and vertebral artery
patients with hypertension and type 2 diabetes
-
decreased significantly
#3
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
pulsatility index of internal cerebral artery and vertebral artery
patients with hypertension and type 2 diabetes
-
decreased significantly
#4
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
resistance index of internal cerebral artery and vertebral artery
patients with hypertension and type 2 diabetes
-
decreased significantly
#5
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
pulsatility index of anterior cerebral artery and middle cerebral artery
patients with hypertension and type 2 diabetes
-
decreased significantly
#6
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
resistance index of anterior cerebral artery and middle cerebral artery
patients with hypertension and type 2 diabetes
-
decreased significantly
#7
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
end-diastolic velocity of basilar artery
patients with hypertension and type 2 diabetes
-
decreased significantly
#8
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
pulsatility index of basilar artery
patients with hypertension and type 2 diabetes
-
decreased significantly
#9
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
Systolic blood pressure
patients with hypertension and type 2 diabetes
-
decreased significantly
#10
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
Diastolic blood pressure
patients with hypertension and type 2 diabetes
-
decreased significantly
#11
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
fasting blood glucose
patients with hypertension and type 2 diabetes
-
decreased significantly
#12
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
decrease
postprandial blood glucose
patients with hypertension and type 2 diabetes
-
decreased significantly
#13
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
increase
Blood pressure control rates
patients with hypertension and type 2 diabetes
-
increased significantly
#14
low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet
increase
blood glucose control rates
patients with hypertension and type 2 diabetes
-
increased significantly
#15
23 % low-sodium formula combined with CM-DASH diet pattern
increase
cerebrovascular function
community patients with hypertension complicated with diabetes
-
can improve
#16
23 % low-sodium formula combined with CM-DASH diet pattern
increase
blood pressure and glucose control
community patients with hypertension complicated with diabetes
-
has a good short-term benefit of
#17
Abstract

Aim: to investigate the effects of low sodium formula salt combined with the Chinese Modified Dietary Approaches to Stop Hypertension (DASH) diet on cerebrovascular function in patients with hypertension and type 2 diabetes. Methods: an eight-week single-arm trial was conducted in 66 patients with hypertension and type 2 diabetes to investigate effects of low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet on cerebrovascular function (measured by transcranial Doppler sonography), indicators of chronic diseases (blood pressure, blood glucose and blood lipids) and urinary excretion. The above indicators were performed before and after intervention. Results: fifty-nine subjects completed the study. Peak systolic velocity, mean flow velocity, end-diastolic velocity, pulsatility index and resistance index of internal cerebral artery and vertebral artery decreased significantly (p < 0.05); pulsatility index and resistance index of anterior cerebral artery and middle cerebral artery decreased significantly (p < 0.05); and end-diastolic velocity and pulsatility index of basilar artery decreased significantly (p < 0.05). Systolic blood pressure, diastolic blood pressure, fasting blood glucose and postprandial blood glucose decreased significantly (p < 0.001; p < 0.001; p < 0.001; p < 0.001). Blood pressure and blood glucose control rates increased significantly (p < 0.001). Conclusions: based on the study, 23 % low-sodium formula combined with CM-DASH diet pattern can improve cerebrovascular function in community patients with hypertension complicated with diabetes and has a good short-term benefit of blood pressure and glucose control.

Medical Subject Headings (MeSH)
HumansBlood GlucoseBlood PressureDiabetes Mellitus, Type 2Diet, Sodium-RestrictedDietary Approaches To Stop HypertensionEast Asian PeopleFatty AlcoholsHypertensionPilot ProjectsSodium Chloride, Dietary
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality70/10
Citation Metrics
Total Citations1
Citations/Year0.5
Relative Citation Ratio0.26
NIH Percentile13.7%
Research Impact Scores
APT Score0.25
Weight Score2.25
Normalized Score0.68
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