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Review of intervention products for use in the prevention and control of anemia.

Annals of the New York Academy of Sciences
November 1, 2023
Daniel Lopez de Romaña et al. (6 authors)
Journal ArticleReviewResearch Support, U.S. Gov't, Non-P.H.S.Research Support, Non-U.S. Gov'tHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the potential of iodine-fortified salt as a promising intervention to prevent anemia.

Results Summary

The study identified iodine-fortified salt as a promising intervention for anemia prevention, though specific efficacy data on iodine alone were not detailed. The abstract suggests it is part of a broader strategy alongside iron fortification.

Population

Vulnerable groups including young children, menstruating adolescent girls and women, and pregnant/postpartum women.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (11)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Daily iron supplementation
decrease
anemia
infants, children, and pregnant women
-
reduces the risk
#1
Intermittent iron supplementation
decrease
anemia risk
menstruating girls and women
-
reduces
#2
Micronutrient powders
decrease
anemia
children
-
reduce the risk
#3
Fortifying wheat flour with iron
decrease
anemia
the overall population
-
reduces the risk
#4
Fortifying maize flour and rice
no change
anemia
-
-
effect is still uncertain
#5
Malaria treatment
decrease
anemia prevalence
-
-
decrease
#6
Deworming
decrease
anemia prevalence
-
-
decrease
#7
Vitamin A supplementation
decrease
anemia
-
-
promising interventions to prevent
#8
Multiple micronutrient supplementation
decrease
anemia
pregnant women
-
promising interventions to prevent
#9
Small-quantity lipid-based supplements
decrease
anemia
-
-
promising interventions to prevent
#10
Fortification of salt with iodine and iron
decrease
anemia
-
-
promising interventions to prevent
#11
Abstract

Anemia remains a major public health problem, especially in low- and middle-income countries. The World Health Organization recommends several interventions to prevent and manage anemia in vulnerable population groups, including young children, menstruating adolescent girls and women, and pregnant and postpartum women. Daily iron supplementation reduces the risk of anemia in infants, children, and pregnant women, and intermittent iron supplementation reduces anemia risk in menstruating girls and women. Micronutrient powders reduce the risk of anemia in children. Fortifying wheat flour with iron reduces the risk of anemia in the overall population, whereas the effect of fortifying maize flour and rice is still uncertain. Regarding non-nutrition-related interventions, malaria treatment and deworming have been reported to decrease anemia prevalence. Promising interventions to prevent anemia include vitamin A supplementation, multiple micronutrient supplementation for pregnant women, small-quantity lipid-based supplements, and fortification of salt with iodine and iron. Future research could address the efficacy and safety of different iron supplementation formulations, identify the most bioavailable form of iron for fortification, examine adherence to supplementation regimens and fortification standards, and investigate the effectiveness of integrating micronutrient, helminth, and malaria control programs.

Medical Subject Headings (MeSH)
InfantChildAdolescentFemaleHumansPregnancyChild, PreschoolIronFood, FortifiedFlourTriticumAnemiaDietary SupplementsTrace ElementsMicronutrientsMalariaAnemia, Iron-Deficiency
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality85/10
Citation Metrics
Total Citations6
Citations/Year3.0
Relative Citation Ratio2.08
NIH Percentile75.8%
Research Impact Scores
APT Score0.50
Weight Score1.41
Normalized Score0.67
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