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Effects of a Gluten-Free Diet in a Teenager Presenting With Psychosis.

Cureus
July 1, 2023
Olfa Selmi et al. (3 authors)
Case ReportsJournal ArticleHuman Study
Study Details

Study Goal

The researchers aimed to investigate the potential relationship between gluten ingestion and psychiatric symptoms in a case of nonceliac gluten sensitivity.

Results Summary

The study found that a strict gluten-free diet led to significant improvement in psychiatric symptoms (anxiety and paranoid delusion) in a patient who did not respond to conventional treatment, suggesting a possible link between gluten and psychiatric disorders.

Population

15-year-old girl with no past psychiatric history presenting with anxiety and paranoid delusion.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (2)
InterventionDirectionEndpointPopulationDosageImpactClaim #
conventional treatment
no change
anxiety symptoms and paranoid delusion
a 15-year-old girl with no past psychiatric history
-
did not improve
#1
a strict gluten-free diet (GFD)
decrease
anxiety symptoms and paranoid delusion
a 15-year-old girl with no past psychiatric history
-
a significant improvement was observed
#2
Abstract

Nonceliac gluten sensitivity is a gluten-related disorder that results from immune-mediated reactions in predisposed people. It manifests usually with gastrointestinal symptoms; however, in rare cases, it might present with psychiatric symptoms that could be severe enough to impair functioning.  In this case report, we present a case of a 15-year-old girl, with no past psychiatric history, who presented to the Emergency Department (ED) with anxiety symptoms and paranoid delusion that did not improve on conventional treatment. However, a significant improvement was observed upon starting on a strict gluten-free diet (GFD). This case adds to the existing literature, suggesting a possible strong relationship between gluten ingestion and psychiatric disorders.

Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality60/10
0
Research Impact Scores
APT Score0.05
Weight Score1.93
Normalized Score0.66
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