A Randomized Controlled Trial of Blood Pressure Reduction Based on Disease Control Priorities 3 in Pakistan to Manage and Control Hypertension.
Study Goal
The researchers aimed to determine if a non-pharmacological, multi-component intervention (including reduced salt intake) could effectively lower high blood pressure in hypertensive patients to the recommended level of 140/90 mm Hg.
Results Summary
The intervention significantly reduced systolic blood pressure by 23.9 mm Hg (p ≤ 0.005) and improved health outcomes, particularly in diet control, reduced salt intake, and increased physical exercise. The mean blood pressure in the intervention group was 145/90 mm Hg for males and 140/100 mm Hg for females.
Population
Hypertensive patients (240 participants, both male and female aged 18 and above) in a hospital setting.
Effective Dosage
Not specified
Duration
3 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
non-pharmacological and multi-component intervention based on Disease Control Priorities (3rd edition) | decrease | high blood pressure | hypertensive patients in a hospital setting | -23.9 mm Hg of systolic blood pressure reduction | significantly reduced | #1 |
non-pharmacological and multi-component intervention based on Disease Control Priorities (3rd edition) | increase | health outcomes | patients in the intervention group | - | improved | #2 |
diet control | increase | health outcomes | patients in the intervention group | - | improved | #3 |
reducing salt intake | increase | health outcomes | patients in the intervention group | - | improved | #4 |
increased physical exercise | increase | health outcomes | patients in the intervention group | - | improved | #5 |
low salt diet, weight loss measures, and increased physical activity | decrease | high blood pressure | hypertensive patients | - | significantly reduced | #6 |
INTRODUCTION: According to American Heart Association standards, hypertension is classified into three stages based on blood pressure measurements: essential hypertension, stage 1 hypertension, and stage 2 hypertension. The global target is to reduce the prevalence of high blood pressure by 25% by the year 2025. Worldwide, the prevalence of high blood pressure among men and women aged 18 and above reported to be 24% and 20%, respectively. AIM: The aim of this study was to overall reduce high blood pressure of hypertensive patients to the recommended level of 140/90 mm of Hg through implementing a non-pharmacological and multi-component intervention based on Disease Control Priorities (3rd edition). METHODS: A randomized controlled trial in which a multi-component intervention for lowering high blood pressure was tested. This was pilot-tested for its acceptance, appropriateness, and relevance, explored through an earlier formative research and desk review conducted from the available evidence. A total of 240 study participants were enrolled after obtaining informed consent. Ethical approval was obtained from the Institutional Review Board of Health Services Academy and the trial was registered in clinicaltrials.gov number NCT04336631. SPSS software version 21 was used to enter and analyze the data. RESULTS: High blood pressure of hypertensive patients in a hospital setting during 03 months yielded -23.9 mm Hg of systolic blood pressure reduction (95% confidence interval, p ≤ 0.005). A significant reduction was observed in intervention group after delivering the intervention. Compared to patients in the usual care group, improved health outcomes were achieved for diet control, reducing salt intake and increased physical exercise. In the intervention group, the mean blood pressure among male hypertensive patients was 145/90 mm Hg and in female hypertensive patients, the mean blood pressure was recorded as 140/100 mm Hg. CONCLUSION: High blood pressure was significantly reduced in hypertensive patients who adhered to a low salt diet, weight loss measures, and increased physical activity.