Advances on novel iron saccharide-iron (III) complexes as nutritional supplements.
Study Goal
The researchers aimed to evaluate the safety, efficacy, and biological activities of saccharide-iron (III) complexes (SICs) as novel iron supplements compared to traditional oral iron supplements.
Results Summary
The study found that SICs have a high iron absorption rate, no gastrointestinal irritation, and exhibit beneficial effects in treating anemia, eliminating free radicals, and regulating immune response.
Population
Not specified (general iron-deficient population implied).
Effective Dosage
Not specified.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
traditional oral supplements such as ferrous sulfate, ferrous succinate, and ferrous gluconate | increase | lipid peroxidation | - | - | leading to | #1 |
traditional oral supplements such as ferrous sulfate, ferrous succinate, and ferrous gluconate | increase | side effects | - | - | leading to | #2 |
saccharide-iron (III) complexes (SICs) | increase | iron absorption rate | - | - | high | #3 |
saccharide-iron (III) complexes (SICs) | no change | gastrointestinal irritation | - | - | no | #4 |
saccharide-iron (III) complexes (SICs) | increase | treating anemia | - | - | exhibited good abilities in | #5 |
saccharide-iron (III) complexes (SICs) | increase | eliminating free radicals | - | - | exhibited good abilities in | #6 |
saccharide-iron (III) complexes (SICs) | increase | regulating the immune response | - | - | exhibited good abilities in | #7 |
Iron deficiency is prevalent worldwide, and iron supplementation is a promising strategy to address iron needs of the body. However, traditional oral supplements such as ferrous sulfate, ferrous succinate, and ferrous gluconate are absorbed in the form of ferrous ions, leading to lipid peroxidation and side effects due to other reasons. In recent years, saccharide-iron (III) complexes (SICs) as novel iron supplements have aroused attention for the high iron absorption rate and no gastrointestinal irritation at oral doses. In addition, research on the biological activities of SICs revealed that they also exhibited good abilities in treating anemia, eliminating free radicals, and regulating the immune response. This review focused on the preparation, structural characterization, and bioactivities of these new iron supplements, as promising candidates for the prevention and treatment of iron deficiency.