The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review.
Study Goal
The researchers aimed to evaluate the effect of vitamin D supplementation on preventing airway remodeling in asthmatic patients, including its impact on collagen synthesis in the airways.
Results Summary
Vitamin D supplementation was found to inhibit airway smooth muscle cell contraction and remodeling, reduce inflammation, regulate collagen synthesis, and modulate bronchial fibroblast action, though TGF-β1 may impair some of these effects.
Population
Asthmatic patients
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation | decrease | airway smooth muscle cell contraction and remodeling | asthmatic patients | - | inhibits | #1 |
vitamin D supplementation | decrease | inflammation | asthmatic patients | - | reduces | #2 |
vitamin D supplementation | neutral | collagen synthesis in the airways | asthmatic patients | - | regulates | #3 |
vitamin D supplementation | neutral | action of bronchial fibroblasts | asthmatic patients | - | modulates | #4 |
vitamin D supplementation | decrease | vitamin D-induced and constitutive airway epithelial host defense mechanisms | - | - | impairs | #5 |
Asthma is a common chronic respiratory disease that affects millions of people worldwide, and its prevalence continues to increase. Vitamin D has been proposed as a potential environmental factor in asthma pathogenesis, due to its immunomodulatory effects. This systematic review aimed to evaluate the effect of vitamin D supplementation in order to prevent airway remodeling in asthmatic patients. Four electronic databases, namely PubMed, Embase, Clinical trails.gov, and CINAHL, were thoroughly searched to conduct a comprehensive literature review. The International Prospective Register of Systematic Reviews (CRD42023413798) contains a record of the registered protocol. We identified 9447 studies during the initial search; 9 studies (0.1%) met the inclusion criteria and were included in the systematic review. All included studies were experimental studies that investigated the impact of vitamin D supplementation on airway remodeling in asthma. The studies included in this review suggest that vitamin D inhibits airway smooth muscle cell contraction and remodeling, reduces inflammation, regulates collagen synthesis in the airways, and modulates the action of bronchial fibroblasts. However, one study suggests that TGF-β1 can impair vitamin D-induced and constitutive airway epithelial host defense mechanisms. Overall, vitamin D appears to have a potential role in the prevention and management of asthma.