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Fatigue-related gait adaptations in children with cerebral palsy.

Developmental medicine and child neurology
December 1, 2023
Laura M Oudenhoven et al. (6 authors)
Observational StudyJournal ArticleResearch Support, Non-U.S. Gov'tHuman StudyClinical
Study Details

Study Goal

The researchers aimed to investigate the effects of fatigue on walking kinematics, kinetics, and energy cost in children with cerebral palsy (CP) compared to typically developing children.

Results Summary

Prolonged walking led to slight deterioration in gait kinematics for both groups, with specific changes in knee and ankle flexion in children with CP. No significant changes were observed in kinetics or energy cost of walking.

Population

12 children with CP (mean age 12 years 9 months) and 15 typically developing children (mean age 10 years 8 months).

Effective Dosage

6-minute walking exercise at comfortable speed, 2 minutes of moderate-intensity walking, and 4 minutes walking after moderate-intensity walking.

Duration

Single session with stages totaling approximately 12 minutes of walking.

Interactions

None mentioned

Extracted Claims (5)
InterventionDirectionEndpointPopulationDosageImpactClaim #
prolonged walking
decrease
Gait Profile Scores
children with cerebral palsy and typically developing children
-
deteriorated slightly
#1
prolonged walking
increase
knee flexion during early stance
children with cerebral palsy
-
increased
#2
prolonged walking
increase
ankle dorsiflexion during late stance
children with cerebral palsy
-
increased
#3
prolonged walking
no change
kinetics
children with cerebral palsy and typically developing children
-
negligible effects were found
#4
prolonged walking
no change
energy cost of walking (ECoW)
children with cerebral palsy and typically developing children
-
no demonstrable change
#5
Abstract

AIM: To obtain insights into the effects of fatigue on the kinematics, kinetics, and energy cost of walking (ECoW) in children with cerebral palsy (CP). METHOD: In this prospective observational study, 12 children with CP (mean age 12 years 9 months, SD 2 years 7 months; four females, eight males) and 15 typically developing children (mean age 10 years 8 months, SD 2 years 4 months; seven females, eight males) followed a prolonged intensity-based walking protocol on an instrumented treadmill, combined with gas analysis measurements. The protocol consisted of consecutive stages, including a 6-minute walking exercise (6MW) at comfortable speed, 2 minutes of moderate-intensity walking (MIW) (with a heart rate > 70% of its predicted maximal), and 4 minutes walking after MIW. If necessary, the speed and slope were incremented to reach MIW. Outcomes were evaluated at the beginning and end of the 6MW and after MIW. RESULTS: With prolonged walking, Gait Profile Scores deteriorated slightly for both groups (p < 0.01). Knee flexion increased during early stance (p = 0.004) and ankle dorsiflexion increased during late stance (p = 0.034) in children with CP only. Negligible effects were found for kinetics. No demonstrable change in ECoW was found in either group (p = 0.195). INTERPRETATION: Kinematic deviations in children with CP are progressive with prolonged walking. The large variation in adaptations indicates that an individual approach is recommended to investigate the effects of physical fatigue on gait in clinical practice.

Medical Subject Headings (MeSH)
MaleFemaleHumansChildCerebral PalsyGaitWalkingExercise TestFatigueBiomechanical Phenomena
Study Links
Quality Scores
SafetyNot Assessed
Efficacy65/10
Quality75/10
0
Research Impact Scores
APT Score0.05
Weight Score2.19
Normalized Score0.61
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