The role of resistance training and creatine supplementation on oxidative stress, antioxidant defense, muscle strength, and quality of life in older adults.
Study Goal
The researchers aimed to evaluate the effects of resistance training combined with creatine monohydrate supplementation on oxidative stress, antioxidant defense, muscle strength, and quality of life in older adults.
Results Summary
Resistance training significantly reduced oxidative stress markers (MDA and 8-OHDG) and increased antioxidant levels (GPX and TAC). It also improved muscle strength and quality of life, with creatine supplementation potentially doubling strength gains.
Population
Non-athlete older adults (mean age 68.1 ± 7.2 years), including men and women.
Effective Dosage
0.1 g/kg of body weight daily (creatine monohydrate).
Duration
10 weeks (3 sessions per week).
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
resistance training | decrease | MDA | older adults | - | a significant decrease | #1 |
resistance training | decrease | 8-OHDG | older adults | - | a significant decrease | #2 |
resistance training | increase | serum levels of GPX | older adults | - | a significant increase | #3 |
resistance training | increase | TAC | older adults | - | a significant increase | #4 |
resistance training | increase | the body's antioxidant system | older adults | - | strengthen | #5 |
resistance training | increase | muscle strength | older adults | - | strengthen | #6 |
resistance training | increase | quality of life | older adults | - | strengthen | #7 |
creatine monohydrate supplementation | increase | strength gained from resistance training | older adults | double | can double the amount of strength gained | #8 |
BACKGROUND: The aim of this study was to evaluate the effect of resistance training (RT) with creatine monohydrate supplementation (CS) on serum levels of OBJECTIVES: This study evaluated the effect of resistance training with creatine monohydrate supplementation on oxidative stress and antioxidant defense, muscle strength and quality of life in older adults. METHODS: We examined 45 non-athlete volunteer older men and women (mean, 68.1 ± 7.2 years old), were randomly selected and divided into three groups of 15: RT with creatine supplementation (RT + CS), RT with placebo (RT + P) and control group. RT protocol was performed for 10 weeks, three sessions per week. Creatine supplement was taken daily at a dose of 0.1 g/kg of body weight, while the placebo group consumed the same amount of starch. Fasting blood samples were taken before the start of program and at the end of the RT period. RESULTS: In the training groups, after 10 weeks of RT, a significant decrease in MDA and 8 - OHDG as well as a significant increase in serum levels of GPX and TAC were observed (in all cases, CONCLUSION: Regular resistance training can be recommended as a very suitable non-pharmacological approach to strengthen the body's antioxidant system, muscle strength and quality of life in older adults. There are no definite findings on the role of creatine on the antioxidant system and quality of life in older adults, but the use of this supplement in addition to RT can double the amount of strength gained from resistance training.