Association of serum homocysteine, folate, and vitamin B
Study Goal
The study aimed to evaluate the effects of the Swank and Wahls diets, including folate and vitamin B, on depression and anxiety symptoms in people with relapsing-remitting multiple sclerosis (RRMS).
Results Summary
The study found significant improvements in depression and anxiety symptoms, as well as mental health inventory scores, in participants following both the Swank and Wahls diets over 12 and 24 weeks. Serum homocysteine levels decreased, and vitamin B levels increased within both groups.
Population
Individuals with relapsing-remitting multiple sclerosis (RRMS) (n = 77).
Effective Dosage
Not specified
Duration
24 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Swank diet | decrease | severity of depression (HADS-D) symptoms | participants with RRMS | - | Significant improvement | #1 |
Wahls diet | decrease | severity of depression (HADS-D) symptoms | participants with RRMS | - | Significant improvement | #2 |
Swank diet | decrease | severity of anxiety (HADS-A) symptoms | participants with RRMS | - | Significant improvement | #3 |
Wahls diet | decrease | severity of anxiety (HADS-A) symptoms | participants with RRMS | - | Significant improvement | #4 |
Swank diet | increase | MHI total | participants with RRMS | - | Significant improvement | #5 |
Wahls diet | increase | MHI total | participants with RRMS | - | Significant improvement | #6 |
Swank diet | increase | MHI subscores | participants with RRMS | - | Significant improvement | #7 |
Wahls diet | increase | MHI subscores | participants with RRMS | - | Significant improvement | #8 |
Swank diet | decrease | serum homocysteine | participants with RRMS | - | significant within-group reduction | #9 |
Wahls diet | decrease | serum homocysteine | participants with RRMS | - | significant within-group reduction | #10 |
Swank diet | increase | serum vitamin B12 | participants with RRMS | - | significant increase | #11 |
Wahls diet | increase | serum vitamin B12 | participants with RRMS | - | significant increase | #12 |
Swank and Wahls dietary interventions, including folate and vitamin B12 | decrease | depression and anxiety symptoms | participants with RRMS | - | improved | #13 |
BACKGROUND: Depression and anxiety are common psychiatric comorbidities among people with multiple sclerosis (MS). Emerging data suggest abnormal serum homocysteine, vitamin B METHODS: In a previously conducted randomized parallel-arm trial, participants with RRMS (n = 77) were randomly allocated to either the Swank or Wahls diets at baseline and followed for 24 weeks. Blood was drawn at four study visits spaced 12 weeks apart: (1) run-in, (2) baseline, (3) 12 weeks, and (4) 24 weeks. Serum vitamin B RESULTS: Significant improvement in severity of depression (HADS-D) and anxiety (HADS-A) symptoms, MHI total, and MHI subscores were seen at 12 and 24 weeks in each diet group. Further, a significant within-group reduction in serum homocysteine and a significant increase in serum vitamin B CONCLUSION: Participants on both Swank and Wahls dietary interventions, including folate and vitamin B