Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review).
Study Goal
The researchers aimed to assess the trend and risk factors of gastric cancer following bariatric bypass surgery.
Results Summary
The study found an increasing trend of gastric cancer cases after bariatric bypass surgery, mostly in the excluded stomach and diagnosed at advanced stages. Risk factors included bile reflux, tobacco smoking, H. pylori infection, and family history of gastric cancer.
Population
Patients who underwent bariatric bypass surgery, particularly those with morbid obesity.
Effective Dosage
Not Assessed
Duration
Not Assessed
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Bariatric bypass surgery | decrease | morbid obesity | - | - | has been an effective treatment | #1 |
Bariatric bypass surgery | increase | gastric cancer | - | - | increasing number of reported cases | #2 |
- | increase | gastric cancer cases after bariatric bypass surgery | - | - | increasing trend | #3 |
- | neutral | gastric cancer cases | - | 77% | mostly located | #4 |
- | neutral | gastric cancer cases | - | advanced stage | diagnosed | #5 |
Tobacco smoking | increase | gastric cancer | - | 17% | risk factor | #6 |
H. pylori infection | increase | gastric cancer | - | 6% | risk factor | #7 |
Family history of gastric cancer | increase | gastric cancer | - | 3% | risk factor | #8 |
Bile reflux | increase | gastric cancer | - | 18% | cancer-promoting factor | #9 |
Bariatric bypass surgery has been an effective treatment for morbid obesity. However, there is an increasing number of reported cases of gastric cancer after bypass surgery. Our systematic review showed an increasing trend of gastric cancer cases after bariatric bypass surgery in the last decade, mostly located in the excluded stomach (77%) and diagnosed in an advanced stage. In addition to known risk factors such as tobacco smoking (17%), H. pylori infection (6%), and family history of gastric cancer (3%), bile reflux, a recently proposed cancer-promoting factor, was also estimated in 18% of the cases. Our data suggest that gastric cancer risk assessment should be considered before gastric bypass surgery, and further investigations are needed to determine the value of post-operative gastric cancer surveillance.