Role of carotenoids in adipose tissue through the AMPK-mediated pathway.
Study Goal
The researchers aimed to outline the mechanism of carotenoids in the AMPK pathway in adipose tissue and their role in regulating adipogenesis, particularly in the context of high-fat diet-induced complications.
Results Summary
The study found that carotenoids can activate the AMPK signaling pathway, leading to improved lipid metabolism, reduced oxidative stress and inflammation, and inhibition of adipogenesis. Different carotenoids were noted to upregulate transcriptional factors, induce white adipose tissue browning, and enhance adiponectin levels.
Population
Not specified (general focus on obesity and high-fat diet-induced metabolic dysregulation).
Effective Dosage
Not provided
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
A high-fat diet (HFD) | null | WAT function | null | null | alters | #1 |
A high-fat diet (HFD) | null | AMP-activated protein kinase (AMPK) | null | null | affects | #2 |
A high-fat diet (HFD) | null | lipolysis and lipid metabolism | adipocytes | null | dysregulating | #3 |
AMPK activation | decrease | oxidative stress and inflammation | null | null | may attenuate | #4 |
carotenoids | increase | AMPK activation | null | null | positive contribution | #5 |
Different carotenoids | increase | AMPK signaling pathway | null | null | act as an agonist | #6 |
Different carotenoids | increase | upstream kinases | null | null | activating | #7 |
Different carotenoids | increase | transcriptional factors | null | null | upregulating | #8 |
Different carotenoids | increase | WAT browning | null | null | inducing | #9 |
Different carotenoids | decrease | adipogenesis | null | null | blocking | #10 |
carotenoids | increase | adiponectin | null | null | improvement | #11 |
improvement of some "homeostatic" factors, such as adiponectin | increase | AMPK activation induced by carotenoids | null | null | may mediate | #12 |
Diet is a critical factor in controlling adiposity and white adipose tissue (WAT) physiology. A high-fat diet (HFD) alters WAT function and affects AMP-activated protein kinase (AMPK) - a cellular sensor - dysregulating lipolysis and lipid metabolism in adipocytes. Otherwise, AMPK activation may attenuate oxidative stress and inflammation. Interest in natural therapies, such as carotenoid consumption or supplementation, is growing due to their health benefits. Carotenoids are lipophilic pigments present in vegetables and fruits, which cannot be synthesized by the human body. Interventions focused on ameliorating complications induced by a HFD indicate a positive contribution of the carotenoids to the AMPK activation. This review aims to outline the mechanism of carotenoids in the AMPK pathway in adipose tissue and their contribution in regulating adipogenesis. Different carotenoids can act as an agonist of the AMPK signaling pathway, activating upstream kinases, upregulating transcriptional factors, inducing WAT browning, and blocking adipogenesis. In addition, the improvement of some "homeostatic" factors, such as adiponectin, may mediate the AMPK activation induced by carotenoids. With these findings, we encourage clinical trials to confirm the role of carotenoids in the AMPK pathway in a long-term treatment, mainly in obesity cases.