Impact of vitamin D3 supplementation on COVID-19 vaccine response and immunoglobulin G antibodies in deficient women: A randomized controlled trial.
Study Goal
The researchers aimed to determine whether vitamin D supplementation could enhance immune response in vitamin D-deficient women following COVID-19 vaccination.
Results Summary
Vitamin D supplementation significantly increased serum 25-Hydroxy Vitamin D levels and IgG levels, with a positive correlation between final IgG and 25(OH)D levels. No significant difference in IgM levels was observed between supplemented and control groups.
Population
Vitamin D-deficient women who received two doses of the COVID-19 vaccine (Pfizer-BioNTech or Sinovac).
Effective Dosage
150,000 IU of vitamin D (single dose).
Duration
Mean follow-up of more than 65 days.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
150,000 IU of vitamin D supplementation | increase | serum 25-Hydroxy Vitamin D levels | vitamin D deficient women who received the COVID-19 vaccine | - | were found to increase regularly | #1 |
150,000 IU of vitamin D supplementation | no change | immunoglobulin M levels | vitamin D deficient women who received the COVID-19 vaccine | - | no significant difference | #2 |
150,000 IU of vitamin D supplementation | increase | immunoglobulin G levels | vitamin D deficient women who received the COVID-19 vaccine | - | reached the peak level | #3 |
150,000 IU of vitamin D supplementation | no change | initial serum immunoglobulin G and 25-Hydroxy Vitamin D levels | vitamin D deficient women who received the COVID-19 vaccine | - | no correlation was found | #4 |
150,000 IU of vitamin D supplementation | increase | immunoglobulin G and 25-Hydroxy Vitamin D levels | vitamin D deficient women who received the COVID-19 vaccine | r=0.558 | a significant positive correlation was found | #5 |
vitamin D supplementation | increase | serum IgG levels | vitamin D deficient women who received the COVID-19 vaccine | - | increased significantly | #6 |
vitamin D supplementation | increase | last measured immunoglobulin G and 25(OH) D levels | vitamin D deficient women who received the COVID-19 vaccine | - | a positive and significant relationship was found | #7 |
BACKGROUND: Immune levels were observed by giving vitamin D supplements to vitamin D deficient women who received the COVID-19 vaccine. METHODS: In the research, there were volunteer women who had received two doses of the COVID-19 vaccine who participated for a mean of more than 65 days. Group D (n=14 Pfizer-BioNTech, 2 Sinovac) received 150,000 IU of vitamin D supplementation, but group C (n=14 Pfizer-BioNTech), 3 Sinovac) no support was provided. RESULTS: When the consumption of vitamin D ends (D group), serum 25-Hydroxy Vitamin D levels were found to increase regularly in the (W3) last measurements (p=0.001). There was no significant difference in immunoglobulin M levels between groups D and C (Control group) (p=0.063). It was observed that the immunoglobulin G levels reached the peak level between the W1 and W2 measurements of the D group (P<0.001) and there were significant differences between the three sizes. Also, no correlation was found between the D group's initial serum immunoglobulin G and 25-Hydroxy Vitamin D levels. However, when the final measurements were examined, a significant positive correlation was found between immunoglobulin G and 25-Hydroxy Vitamin D levels (r=0.558, p=0.031). CONCLUSION: It was determined that serum IgG levels increased significantly depending on the duration between those who used vitamin D and those who did not and it was above the initial level for a long time. A positive and significant relationship was found between the last measured immunoglobulin G and 25(OH) D levels while vitamin D supplementation continued. TRIAL REGISTRATION: This study registered under ClinicalTrials.gov (Identifier no. NCT05447065).