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Update on treatment of abdominal pain in irritable bowel syndrome: A narrative review.

Pharmacology & therapeutics
May 1, 2023
Michael Camilleri et al. (2 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the effectiveness of mindfulness as a behavioral therapy for global symptoms and pain relief in irritable bowel syndrome (IBS).

Results Summary

The study found that mindfulness, along with other behavioral therapies, demonstrated only modest benefit in improving global IBS symptoms and pain relief. Current evidence suggests limited efficacy compared to other interventions.

Population

Patients with irritable bowel syndrome (IBS).

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (5)
InterventionDirectionEndpointPopulationDosageImpactClaim #
medications
no change
global IBS symptoms and pain relief
patients with irritable bowel syndrome (IBS)
modest benefit
demonstrates only modest benefit
#1
dietary interventions including low fermentable oligosaccharides, disaccharides, and monosaccharides and polyols (FODMAP) diet
no change
global IBS symptoms and pain relief
patients with irritable bowel syndrome (IBS)
modest benefit
demonstrates only modest benefit
#2
fecal microbial transplantation (FMT)
no change
global IBS symptoms and pain relief
patients with irritable bowel syndrome (IBS)
modest benefit
demonstrates only modest benefit
#3
electrical approaches
no change
global IBS symptoms and pain relief
patients with irritable bowel syndrome (IBS)
modest benefit
demonstrates only modest benefit
#4
behavioral therapies including cognitive behavioral therapy (CBT), gut-directed hypnotherapy (GDH), mindfulness, and open-label placebo
no change
global IBS symptoms and pain relief
patients with irritable bowel syndrome (IBS)
modest benefit
demonstrates only modest benefit
#5
Abstract

The objectives of this narrative review are to update readers on the current state-of-the-art regarding diverse approaches for the treatment of pain, global symptoms, or adequate relief in irritable bowel syndrome (IBS). The article appraises medications, dietary interventions including low fermentable oligosaccharides, disaccharides, and monosaccharides and polyols (FODMAP) diet, fecal microbial transplantation (FMT), electrical approaches, and behavioral therapies including cognitive behavioral therapy (CBT), gut-directed hypnotherapy (GDH), mindfulness, and open-label placebo. Current evidence demonstrates only modest benefit in global IBS symptoms and pain relief. A future approach that identifies pathophysiological mechanisms of IBS through validated biomarkers has the potential to individualize treatment of patients rather than sequential therapeutic trial and error approaches.

Medical Subject Headings (MeSH)
HumansIrritable Bowel SyndromeFermentationDisaccharidesOligosaccharidesDietAbdominal Pain
Study Links
Quality Scores
SafetyNot Assessed
Efficacy50/10
Quality70/10
Citation Metrics
Total Citations8
Citations/Year4.0
Relative Citation Ratio1.85
NIH Percentile72.2%
Research Impact Scores
APT Score0.25
Weight Score1.28
Normalized Score0.54
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