Effects of Lactobacillus acidophilus administration to anorexigenic neuropeptides and some biochemical parameters on rats fed with a high-fat diet.
Study Goal
The researchers aimed to investigate the effects of Lactobacillus acidophilus on anorexigenic peptides and biochemical parameters in rats exposed to a high-fat diet.
Results Summary
L. acidophilus supplementation reduced triglyceride and total cholesterol levels, lowered leptin levels, and increased GLP-1 and serotonin levels, suggesting positive effects on obesity-related markers.
Population
Rats fed a high-fat diet.
Effective Dosage
Not specified.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
high-fat diet | increase | body weight and body mass index | Group 2 (rats) | - | there was an increase | #1 |
high-fat diet | increase | AST, ALT, TG, TC, glucose, leptin in the serum | Group 2 (rats) | - | were significantly high | #2 |
high-fat diet | decrease | GLP-1 and serotonin in the serum and in the brain | Group 2 (rats) | - | were significantly low | #3 |
L. acidophilus probiotic | decrease | TG and TC | Groups 3 and 4 (rats) | - | significant decrease | #4 |
high-fat diet | increase | leptin hormone levels in serum and brain | Group 2 (rats) | - | were significantly higher | #5 |
high-fat diet | decrease | GLP-1 and serotonin levels | Group 2 (rats) | - | were found to be significantly low | #6 |
L. acidophilus probiotic | decrease | leptin levels in the serum | Groups 3 and 4 (rats) | - | decreased significantly | #7 |
L. acidophilus probiotic supplementation in high-fat diet | increase | anorexigenic peptides | rats | - | had positive effects | #8 |
AIM: One of the rapidly rising global public health concern is obesity. Over the past three decades, the prevalence of obesity has doubled/tripled in several nations around the world, most likely as a result of urbanization, sedentary lifestyles, and increased intake of high-calorie processed foods. In this study, it was aimed to investigate the effects of Lactobacillus acidophilus administration on rats exposed to high-fat diet experimentally on anorexigenic peptides in the brain and some biochemical parameters in the serum. METHODS: In the study, 4 different experimental groups were formed. Group 1 was designated as the control group and fed with a standard rat chow (SD). Group 2 was designated as the high-fat diet (HFD) fed group. Group 3 fed with SD and L. acidophilus probiotic administered. Group 4 fed with HFD and L. acidophilus probiotic administered. At the end of the experiment, leptin, serotonin, glucagon-like peptide-1 (GLP-1) levels were measured in the brain tissue and serum. Glucose, total cholesterol (TC), triglyceride (TG), total protein (TP), albumin, uric acid, aspartate transaminase (AST), alanine aminotransferase (ALT) levels were determined in the serum. RESULTS: At the end of the study, it was found that there was an increase in body weight and body mass index in Group 2 compared to Group 1. It was determined that the levels of AST, ALT, TG, TC, glucose, leptin in the serum were significantly high (P < 0.05). The levels of GLP-1 and serotonin in the serum and in the brain were significantly low (P < 0.05). There was a significant decrease in TG and TC in Groups 3 and 4 compared to Group 2 (P < 0.05). The leptin hormone levels in serum and brain were significantly higher in Group 2 than in other groups (P < 0.05). GLP-1 and serotonin levels were found to be significantly low (P < 0.05). The leptin levels in the serum of Groups 3 and 4 decreased significantly compared to Group 2 (P < 0.05). CONCLUSION: It was found that probiotic supplementation in high-fat diet had positive effects on anorexigenic peptides. It was concluded that L. acidophilus probiotic can be recommended as a food supplement in the treatment of obesity.