The association of MIND diet with cognitive resilience to neuropathologies.
Study Goal
The researchers aimed to determine the association between the MIND diet (a hybrid of the Mediterranean and DASH diets) and cognitive resilience, measured by higher cognitive levels and slower cognitive decline relative to neuropathology.
Results Summary
Higher adherence to the MIND diet was associated with better cognitive resilience, including higher cognitive levels (mean difference = 0.34) and slower cognitive decline (mean difference = 0.27) compared to the lowest tertile of MIND diet adherence, after adjusting for neuropathology. The overall MIND diet score showed a stronger association with cognitive resilience than its individual food components.
Population
578 deceased older adults with longitudinal cognitive data and post-mortem neuropathology.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet | increase | CR Level | deceased older adults | mean difference = 0.34; 95% confidence interval = 0.14, 0.55 | had higher | #1 |
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet | increase | CRSlope | deceased older adults | mean difference = 0.27; 95% confidence interval = 0.05, 0.48 | had higher | #2 |
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet | increase | cognition and cognitive decline | deceased older adults | - | is associated with both higher cognition and slower rates of cognitive decline | #3 |
INTRODUCTION: Cognitive resilience (CR) can be defined as the continuum of better through worse than expected cognition, given the degree of neuropathology. The relation of healthy diet patterns to CR remains to be elucidated. METHODS: Using longitudinal cognitive data and post mortem neuropathology from 578 deceased older adults, we examined associations between the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet at baseline and two standardized CR measures reflecting higher cognitive levels over time (CR Level ¯ $_{\overline {{\rm{Level}}}} $ ), and slower decline (CRSlope ), than expected given neuropathology. RESULTS: Compared to individuals in the lowest tertile of MIND score, those in the top tertile had higher CR Level ¯ $_{\overline {{\rm{Level}}}} $ (mean difference [MD] = 0.34; 95% confidence interval [CI] = 0.14, 0.55) and CRSlope (MD = 0.27; 95% CI = 0.05, 0.48), after multivariable adjustment. Overall MIND score was more strongly related to CR than the individual food components. DISCUSSION: The MIND diet is associated with both higher cognition and slower rates of cognitive decline, after controlling for neuropathology, indicating the MIND diet may be important to cognitive resilience.