Sumac (Rhus coriaria L.) powder supplementation has beneficial effects on appetite in overweight/obese women with depression: A randomized controlled trial.
Study Goal
The researchers aimed to investigate the effects of sumac (a polyphenol-rich supplement) combined with a calorie-restricted diet on appetite and metabolic markers in overweight and obese women with depression.
Results Summary
Sumac supplementation significantly reduced appetite scores, leptin, NPY, insulin, FBS, and HOMA-IR while increasing QUICKI compared to placebo, suggesting improved appetite regulation and metabolic health.
Population
Overweight and obese women with depression.
Effective Dosage
3 g/day of sumac.
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
sumac supplementation along with calorie restricted diet (CRD) | decrease | appetite score | overweight and obese women with depression | - | significantly reduced | #1 |
sumac supplementation along with calorie restricted diet (CRD) | decrease | serum levels of leptin | overweight and obese women with depression | - | significantly reduced | #2 |
sumac supplementation along with calorie restricted diet (CRD) | decrease | serum levels of neuropeptide Y (NPY) | overweight and obese women with depression | - | significantly reduced | #3 |
sumac supplementation along with calorie restricted diet (CRD) | decrease | serum levels of insulin | overweight and obese women with depression | - | significantly reduced | #4 |
sumac supplementation along with calorie restricted diet (CRD) | decrease | fasting blood sugar (FBS) | overweight and obese women with depression | - | significantly reduced | #5 |
sumac supplementation along with calorie restricted diet (CRD) | decrease | homeostasis model assessment of insulin resistance (HOMA-IR) | overweight and obese women with depression | - | significantly reduced | #6 |
sumac supplementation along with calorie restricted diet (CRD) | increase | quantitative insulin sensitivity check index (QUICKI) | overweight and obese women with depression | - | increased significantly | #7 |
BACKGROUND AND PURPOSE: Appetite disturbance is a common problem in obesity and depression. The beneficial effects of polyphenols in promoting satiety have been shown. This study aimed to investigate the effects of sumac supplementation along with calorie restricted diet (CRD) on appetite in overweight and obese women with depression. MATERIALS AND METHODS: In this trial, 60 overweight and obese women with depression were randomly assigned to receive a CRD plus 3 g/day of either sumac or placebo for 12 weeks. The appetite score, serum levels of leptin, neuropeptide Y (NPY), insulin, fasting blood sugar (FBS), homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI) were assessed at baseline and at the end of the study. RESULTS: Sumac supplementation significantly reduced the appetite score (p = 0.02), serum levels of leptin (p = 0.03), NPY (p = 0.01), insulin (p = 0.03), FBS (p = 0.03), and HOMA-IR (p = 0.02) compared to the placebo group. QUICKI increased significantly in the sumac group compared to the placebo group (p = 0.009). CONCLUSION: Sumac along with a CRD may have some beneficial effects on appetite through possible modulatory effects on leptin resistance, insulin sensitivity, and NPY levels in overweight and obese women with depression.