Better adherence to the MIND diet is associated with lower risk of all-cause death and cardiovascular death in patients with atherosclerotic cardiovascular disease or stroke: a cohort study from NHANES analysis.
Study Goal
The researchers aimed to determine whether better adherence to the MIND diet was associated with improved outcomes, specifically reduced all-cause and cardiovascular mortality, in patients with atherosclerotic cardiovascular disease (ASCVD) or stroke.
Results Summary
The study found that higher adherence to the MIND diet was significantly associated with lower risks of all-cause and cardiovascular mortality in ASCVD patients, with hazard ratios showing a dose-response relationship. Each one-score increase in MIND diet adherence was linked to a 10% lower risk of all-cause mortality and a 16% lower risk of cardiovascular mortality.
Population
943 patients with ASCVD or stroke from the NHANES 2003-2006 cohort.
Effective Dosage
Not specified (diet adherence scored as ≤7.0, 7.5-8.0, and ≥8.5).
Duration
Not specified (prospective cohort study).
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet | increase | cognitive performance and dementia | - | - | contributes to better cognitive performance and attenuates dementia | #1 |
MIND diet | decrease | atherosclerotic cardiovascular disease (ASCVD) | - | - | cardioprotective effects have been demonstrated | #2 |
better adherence to the MIND diet | decrease | all-cause and CV death | patients with ASCVD or stroke | hazard ratio [HR] and 95% confidence interval [CI] were 1.09 (0.78, 1.52) in the group of 7.5-8.0, 0.66 (0.50, 0.87) in the group of ≥8.5 for all-cause mortality; 0.70 (0.42, 1.17) in the group of 7.5-8.0 and 0.52 (0.35, 0.75) in the group of ≥8.5 for CV mortality | presented a significantly lower risk of all-cause and CV death | #3 |
per one-score increase in the MIND diet score | decrease | all-cause mortality | patients with ASCVD or stroke | 10% (HR = 0.90, 95% CI: 0.82, 0.99) | was associated with a lower risk of all-cause mortality | #4 |
per one-score increase in the MIND diet score | decrease | CV mortality | patients with ASCVD or stroke | 16% (HR = 0.84, 95% CI: 0.73, 0.97) | was associated with a lower risk of CV mortality | #5 |
better adherence to the MIND diet | increase | outcomes | patients with ASCVD | - | was associated with improved outcomes | #6 |
The Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet has been evaluated as a brain-protective diet pattern that contributes to better cognitive performance and attenuates dementia. Cardioprotective effects of the MIND diet have been demonstrated in the primary prevention of atherosclerotic cardiovascular disease (ASCVD), however, there is no exploration in patients with ASCVD. In this prospective cohort study, 943 patients with ASCVD or stroke from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2006 were enrolled and divided into three groups according to the MIND diet scores (≤7.0, 7.5-8.0, and ≥8.5). Compared with patients with low MIND diet scores (≤7.0), patients with better adherence to the MIND diet presented a significantly lower risk of all-cause and CV death, as results showed that the hazard ratio [HR] and 95% confidence interval [CI] were 1.09 (0.78, 1.52) in the group of 7.5-8.0, 0.66 (0.50, 0.87) in the group of ≥8.5 for all-cause mortality (P trend = 0.002); 0.70 (0.42, 1.17) in the group of 7.5-8.0 and 0.52 (0.35, 0.75) in the group of ≥8.5 for CV mortality (P for trend < 0.001). Besides, per one-score increase in the MIND diet score was associated with a 10% (HR = 0.90, 95% CI: 0.82, 0.99) lower risk of all-cause mortality and a 16% (HR = 0.84, 95% CI: 0.73, 0.97) lower risk of CV mortality in these patients. In conclusion, this study, for the first time, revealed that better adherence to the MIND diet was associated with improved outcomes in patients with ASCVD.