Spontaneous Latency in Adult Patients with Celiac Disease on a Normal Diet after Gluten-Free Diet: Case Series.
Study Goal
The researchers aimed to determine whether some adult celiac disease patients could achieve complete remission on a gluten-containing diet after long-term adherence to a gluten-free diet.
Results Summary
The study found that five celiac disease patients achieved complete remission of symptoms, histopathological changes, and serology despite reintroducing a gluten-containing diet after a mean of 4 years on a gluten-free diet. The results suggest that some adult-diagnosed celiac patients may recover normal mucosa without relapse.
Population
Adult patients with celiac disease confirmed by positive TTG IgA and duodenal biopsy.
Effective Dosage
Not specified
Duration
Mean 4 (±0.54) years on gluten-free diet
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
gluten-free diet | decrease | symptoms | patients with CeD | complete disappearance | complete disappearance of symptoms | #1 |
gluten-containing diet | decrease | clinical symptoms, histopathological changes, and serology | five patients with CeD | complete remission | complete remission of clinical symptoms, histopathological changes, and serology | #2 |
gluten-containing diet | increase | mucosa | some CeD patients diagnosed in adulthood | normal | recover a normal mucosa | #3 |
gluten-containing diet | no change | clinical or biological symptoms of CeD | some CeD patients diagnosed in adulthood | without relapsing | without relapsing any clinical or biological symptoms | #4 |
Celiac disease (CeD) is an immune condition induced by the consumption of gluten-containing foods in genetically-predisposed persons. CeD, in addition to digestive disease, is a multisystem disorder. If untreated, it is potentially can be a dangerous disorder and lead to morbidity and even mortality. At present, the only treatment option is a lifelong gluten-free diet (GFD), and all authors recommended this regimen. To the best of our knowledge, there are rare reports of the complete remission of disorder on GFD and reintroduction of a normal diet in affected patients. In this report, we describe five patients with CeD who developed complete remission of clinical symptoms, histopathological changes, and serology on a gluten-containing diet. All patients had CeD based on a positive tissue transglutaminase antibody (TTG IgA) and typical histopathological changes in duodenal biopsy with the complete disappearance of symptoms on the GFD regimen. All patients followed GFD for a mean 4 (±0.54) years. In conclusion, this study has shown that some CeD patients diagnosed in adulthood can recover a normal mucosa after a long period of the gluten-containing diet without relapsing any clinical or biological symptoms of CeD.