Cordyceps militaris polysaccharides modulate gut microbiota and improve metabolic disorders in mice with diet-induced obesity.
Study Goal
The researchers aimed to determine whether Cordyceps militaris polysaccharides (CMP) could mitigate obesity-related metabolic disorders and gut dysbiosis in mice.
Results Summary
CMP significantly reduced obesity, hyperlipidemia, insulin resistance, and systemic inflammation in high-fat diet-induced obese mice. It also restored gut microbiota diversity and increased beneficial SCFA-producing bacteria while reducing obesity-linked bacterial strains.
Population
High-fat diet-induced obese mice.
Effective Dosage
Not specified.
Duration
4 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
CMP diet intervention | decrease | HFD-induced obesity | mice with obesity induced by a high-fat diet | - | significantly reduce | #1 |
CMP | decrease | obesity-induced hyperlipidemia | mice with obesity induced by a high-fat diet | - | alleviate | #2 |
CMP | decrease | insulin resistance | mice with obesity induced by a high-fat diet | - | alleviate | #3 |
CMP | decrease | systemic inflammation | mice with obesity induced by a high-fat diet | - | ameliorate | #4 |
CMP | decrease | mice from obesity | mice with obesity induced by a high-fat diet | - | protect | #5 |
CMP | neutral | obesity-induced gut dysbiosis | mice with obesity induced by a high-fat diet | - | regulate | #6 |
CMP | increase | phylogenetic diversity of gut microbiota | mice with obesity induced by a high-fat diet | - | restoring | #7 |
CMP | increase | relative abundance of short-chain fatty acid (SCFA)-producing bacteria | mice with obesity induced by a high-fat diet | - | increase | #8 |
CMP | decrease | level of bacteria that were positively related to the development of obesity | mice with obesity induced by a high-fat diet | - | down-regulating | #9 |
BACKGROUND: Cordyceps militaris is an edible and medicinal fungus, and its polysaccharides are among its main pharmacological components. They can display immunomodulation, anti-oxidation, anti-inflammation, anti-hypolipidemic, and other functions. The anti-obesity effect of C. militaris polysaccharides (CMP) is not yet fully understood, however. RESULTS: In this study, a CMP diet intervention was applied over a 4 week period to mice with obesity induced by a high-fat diet (HFD), followed by profiling of obesity-induced dyslipidemia, low-grade inflammation, and gut dysbiosis. The results suggested that CMP could significantly reduce HFD-induced obesity, alleviate obesity-induced hyperlipidemia and insulin resistance, and ameliorate systemic inflammation, showing a promising ability to protect mice from obesity. Further analyses revealed that CMP could regulate obesity-induced gut dysbiosis by restoring the phylogenetic diversity of gut microbiota. It could also increase the relative abundance of short-chain fatty acid (SCFA)-producing bacteria, while down-regulating the level of bacteria that were positively related to the development of obesity. A correlation analysis showed that Helicobacter, Allobaculum, Clostridium XVIII, Parabacteroides, Ligilactobacillus, Faecalibaculum, Adlercreutzia, and Mediterraneibacter were positively related to obese phenotypes. CONCLUSION: This study highlights the potential of CMP as a prebiotic agent to protect obese individuals from metabolic disorders and gut dysbiosis. © 2022 Society of Chemical Industry.