Low to moderate adherence to 2018 diet and physical exercise recommendations of the World Cancer Research Fund/American Institute for Cancer Research is associated with prooxidant biochemical profile in women undergoing adjuvant breast cancer treatment.
Study Goal
The researchers aimed to investigate whether adherence to WCRF/AICR diet and exercise recommendations affects oxidative stress biomarkers and antioxidant status in breast cancer survivors undergoing adjuvant treatment.
Results Summary
High adherence to WCRF/AICR recommendations was associated with lower oxidative damage biomarkers (lipid hydroperoxides, carbonylated proteins) and higher antioxidant capacity (reduced glutathione) after adjuvant treatment. The WCRF/AICR score at baseline was inversely linked to changes in oxidative stress markers post-treatment.
Population
Women with breast cancer undergoing adjuvant treatment (n=78).
Effective Dosage
Not specified (adherence to dietary/exercise recommendations scored, not direct antioxidant supplementation).
Duration
Evaluated before and after adjuvant treatment (exact duration not specified).
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
adherence to the 2018 diet and exercise recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) | decrease | oxidative stress | breast cancer survivors | - | can possibly result in less | #1 |
adherence to the 2018 diet and exercise recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) | decrease | chemo- and radiotoxicity | breast cancer survivors | - | can possibly result in lower risk to | #2 |
adherence to the 2018 diet and exercise recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) | decrease | relapse | breast cancer survivors | - | can possibly result in lower risk of | #3 |
adherence to the 2018 diet and exercise recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) | increase | quality of life | breast cancer survivors | - | can possibly result in increased | #4 |
adherence to updated recommendations of the WCRF/AICR | decrease | oxidative damage biomarkers | women with breast cancer undergoing adjuvant treatment | - | is inversely related to | #5 |
adherence to updated recommendations of the WCRF/AICR | increase | antioxidant status | women with breast cancer undergoing adjuvant treatment | - | is directly associated with | #6 |
low-medium adherence to WCRF/AICR recommendations at T0 | decrease | reduced glutathione | women with breast cancer undergoing adjuvant treatment | - | affected lower levels of | #7 |
low-medium adherence to WCRF/AICR recommendations at T0 | increase | lipid hydroperoxides | women with breast cancer undergoing adjuvant treatment | - | affected higher levels of | #8 |
low-medium adherence to WCRF/AICR recommendations at T0 | increase | plasma carbonylated proteins | women with breast cancer undergoing adjuvant treatment | - | affected higher levels of | #9 |
WCRF/AICR score at T0 | decrease | plasma carbonylated protein concentrations after AT | women with breast cancer undergoing adjuvant treatment | - | was inversely associated with changes in | #10 |
high WCRF/AICR score before and during AT | increase | antioxidant capacity | women with breast cancer undergoing adjuvant treatment | - | may provide greater stability of | #11 |
high WCRF/AICR score before and during AT | decrease | oxidative stress | women with breast cancer undergoing adjuvant treatment | - | may provide protection against exacerbated | #12 |
Adequate adherence to the 2018 diet and exercise recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) can possibly result in less oxidative stress, lower risk to chemo- and radiotoxicity, lower risk of relapse, and increased quality of life in breast cancer survivors. This observational study aims to investigate the influence of adherence to updated recommendations of the WCRF/AICR on oxidative stress biomarkers in women with breast cancer undergoing adjuvant treatment (AT). We hypothesized that adherence to WCRF/AICR recommendations is inversely related to oxidative damage biomarkers and directly associated with antioxidant status. Women (n = 78) were evaluated before (T0) and after AT. After collecting anthropometric, physical activity, and food consumption data, a standardized score of adherence to WCRF/AICR recommendations was applied. The sample was divided into low-medium adherence and high adherence groups. Blood samples were collected at both timepoints for oxidative stress biomarkers analysis. Multiple linear regression analyzes were applied to verify associations between WCRF/AICR score and biomarkers. We found that low-medium adherence to WCRF/AICR recommendations at T0 affected lower levels of reduced glutathione (P= .003) and higher levels of lipid hydroperoxides (P= .002) and plasma carbonylated proteins (P= .001) after AT. The WCRF/AICR score at T0 was inversely associated with changes in plasma carbonylated protein concentrations after AT (adjusted β = -0.359; P= .01). Our findings suggest that high WCRF/AICR score before and during AT may provide greater stability of antioxidant capacity and protection against exacerbated oxidative stress.