The Effect of Walking Combined with Neuromuscular Electrical Stimulation on Liver Stiffness and Insulin Resistance in Patients with Non-alcoholic Fatty Liver Disease: An Exploratory Randomized Controlled Trial.
Study Goal
The researchers aimed to compare the effects of walking exercise with and without simultaneous hybrid training system (HTS) on liver stiffness and insulin resistance in NAFLD patients.
Results Summary
The study found that walking exercise combined with HTS improved liver stiffness and insulin resistance compared to walking alone, as measured by transient elastography and homeostasis model assessment. Other metabolic markers like fasting blood glucose and liver enzymes were also evaluated.
Population
32 subjects with nonalcoholic fatty liver disease (NAFLD) and BMI of 27 kg/m².
Effective Dosage
Triweekly 30-minute sessions of walking at 5.6 km/h with HTS.
Duration
12 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
walking exercise with simultaneous HTS | neutral | liver stiffness | subjects with NAFLD | - | compared the effect | #1 |
walking exercise with simultaneous HTS | neutral | insulin resistance | subjects with NAFLD | - | compared the effect | #2 |
walking exercise without HTS | neutral | liver stiffness | subjects with NAFLD | - | compared the effect | #3 |
walking exercise without HTS | neutral | insulin resistance | subjects with NAFLD | - | compared the effect | #4 |
Increased liver stiffness and insulin resistance are important therapeutic targets in patients with nonalcoholic fatty liver disease (NAFLD). A hybrid training system (HTS) has been developed which combines application of electrical stimulation and volitional contractions. We compared the effect of walking exercise (5.6 km/h) both with and without simultaneous HTS on liver stiffness and insulin resistance. In a single-blind, controlled trial, 32 subjects with NAFLD were randomized to 12 weeks of triweekly 30 minute walking exercise with either HTS (HTS group) or without HTS (control group). Transient elastography for the assessment of liver stiffness, body weight, visceral fat, the homeostasis model assessment of insulin resistance, fasting blood glucose, serum aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase were evaluated. Data were evaluated using the linear model after adjusting the baseline value. In the subjects with BMI of 27 kg/m