High Doses of Caffeine Increase Muscle Strength and Calcium Release in the Plasma of Recreationally Trained Men.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
8 mg·kg bw−1 of caffeine | increase | bench press strength | recreationally resistance-trained participants | 100.1 ± 1.9 kg vs 94.2 ± 2.5 kg (PLA) | significantly improved | #1 |
8 mg·kg bw−1 of caffeine | increase | deadlift strength | recreationally resistance-trained participants | 132.8 ± 3.5 kg vs 120.7 ± 5.7 kg (PLA) | significantly improved | #2 |
8 mg·kg bw−1 of caffeine | increase | squat strength | recreationally resistance-trained participants | 130.1 ± 4.9 kg vs 119.4 ± 5.4 kg (PLA) | significantly improved | #3 |
8 mg·kg bw−1 of caffeine | increase | calcium release in plasma | recreationally resistance-trained participants | - | significantly increased | #4 |
6 mg·kg bw−1 of caffeine | no change | calcium release in plasma | recreationally resistance-trained participants | - | no changes were observed | #5 |
placebo | no change | calcium release in plasma | recreationally resistance-trained participants | - | no changes were observed | #6 |
The effects of acute caffeine supplementation on muscular strength remain unclear. We examined the effects of two different doses of caffeine on muscle strength and calcium in plasma compared to placebo using a crossover, randomized, double-blind, placebo-controlled design. Twenty-one (n = 21) recreationally resistance-trained participants were randomly assigned into three experimental conditions: 6 mg·kg bw−1 of caffeine (CF6); 8 mg·kg bw−1 of caffeine (CF8); or placebo (PLA), with a 7-day washout period between conditions. Muscular strength assessments were made for both upper (bench press) and lower body muscles (squat and deadlift). Calcium release in plasma was measured on five different occasions. Bench press (CF8: 100.1 ± 1.9 kg; PLA: 94.2 ± 2.5 kg), deadlift (CF8: 132.8 ± 3.5 kg; PLA: 120.7 ± 5.7 kg), and squat (CF8: 130.1 ± 4.9 kg; PLA 119.4 ± 5.4 kg) strength were all significantly (p < 0.001) improved in CF8 compared to PLA. Calcium release in plasma was significantly increased in CF8, whereas no changes were observed in CF6 or PLA. Overall, 8 mg·kg bw−1 of caffeine appears to be an effective dose to optimize upper and lower body muscular strength and calcium release in recreationally trained participants.