Influence of maternal obesity on the skeletal muscle of offspring.
Study Goal
The researchers aimed to review the effects of maternal high-fat diet (obesogenic environment) on skeletal muscle tissue composition and metabolic signaling pathways in offspring.
Results Summary
The study found that fetal exposure to an obesogenic maternal diet alters skeletal muscle morphology, composition, and metabolic pathways, including glucose and fatty acid metabolism, mitochondrial biogenesis, and oxidative phosphorylation. These changes suggest long-term metabolic consequences for offspring.
Population
Offspring of mothers with obesity during pregnancy.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
fetal exposure to an obesogenic maternal diet | neutral | multiple organs and tissues, including skeletal muscle | fetus | - | affects | #1 |
fetal exposure to an obesogenic maternal diet | neutral | morphology and composition of skeletal muscle tissue | fetus | - | described alterations in | #2 |
maternal obesity during pregnancy | neutral | signaling pathways related to the metabolism of energy substrates | children born to mothers with obesity | - | found modifications in | #3 |
fetal exposure to an obesogenic maternal diet | neutral | skeletal muscle tissue | fetus | - | consequences on | #4 |
fetal exposure to an obesogenic maternal diet | neutral | tissue composition | fetus | - | changes in | #5 |
fetal exposure to an obesogenic maternal diet | neutral | signaling pathways related to glucose and fatty acid metabolism | fetus | - | alterations in | #6 |
fetal exposure to an obesogenic maternal diet | neutral | mitochondrial biogenesis | fetus | - | alterations in | #7 |
fetal exposure to an obesogenic maternal diet | neutral | oxidative phosphorylation | fetus | - | alterations in | #8 |
Maternal obesity has been described as a clinical entity associated with an increased incidence of metabolic diseases in the offspring, indicating a fetal programming phenomenon during this critical development period. Fetal exposure to an obesogenic environment affects multiple organs and tissues, including skeletal muscle, which is particularly susceptible to stressors from the external environment. Several studies have described alterations in the morphology and composition of skeletal muscle tissue secondary to obesogenic exposure in utero. In addition, modifications in signaling pathways related to the metabolism of energy substrates have been found in children born to mothers with obesity during pregnancy. This review addresses the current evidence describing the consequences of fetal exposure to an obesogenic maternal diet on skeletal muscle tissue, focusing on changes in tissue composition, alterations in signaling pathways related to glucose and fatty acid metabolism, mitochondrial biogenesis, and oxidative phosphorylation. La obesidad materna se ha descrito como una entidad clínica asociada con el aumento en la incidencia de enfermedades metabólicas en el producto de la gestación, lo que indica la existencia de un fenómeno de programación fetal que se lleva a cabo durante este periodo crítico del desarrollo. La exposición del feto a un ambiente obesogénico afecta múltiples órganos y tejidos, incluyendo el músculo esquelético, el cual es particularmente susceptible a estresores del ambiente externo. Diversos estudios han descrito alteraciones en la morfología y composición del tejido muscular esquelético secundarias a una exposición obesogénica in utero. Además, se han encontrado modificaciones en vías de señalización relacionadas al metabolismo de sustratos energéticos en los productos de madres con obesidad durante la gestación. En la presente revisión se aborda la evidencia actual que describe las consecuencias de la exposición fetal a una dieta materna obesogénica sobre el tejido muscular esquelético, con especial enfoque en los cambios en la composición del tejido, las alteraciones en las vías de señalización relacionadas con el metabolismo de la glucosa y los ácidos grasos, así como la biogénesis mitocondrial y la fosforilación oxidativa.