Possible effects of dietary advanced glycation end products on maternal and fetal health: a review.
Study Goal
The researchers aimed to examine the potential negative effects of dietary advanced glycation end products (AGEs) on maternal and fetal health during pregnancy.
Results Summary
The study suggests that excessive AGE accumulation may increase oxidative stress and inflammation, leading to adverse maternal and fetal outcomes such as gestational diabetes, preeclampsia, intrauterine growth retardation, and neurobehavioral developmental disorders. The mechanisms of these complications remain unconfirmed, requiring further clinical studies.
Population
Pregnant women and their fetuses.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Excessive accumulation of advanced glycation end products (AGEs) | increase | many adverse health conditions | - | - | has been associated with | #1 |
Excessive accumulation of advanced glycation end products (AGEs) | increase | oxidative stress and inflammation | - | - | associated at this point is | #2 |
maintaining an AGE-rich diet | increase | the body's AGE pool | mother | - | may cause an increase in | #3 |
maintaining an AGE-rich diet | increase | oxidative stress and inflammation | mother | - | may increase | #4 |
maternal AGE levels | decrease | maternal and fetal health during pregnancy | - | - | negative effects of | #5 |
maternal AGE levels | increase | gestational diabetes, preeclampsia, endothelial dysfunction, and pelvic diseases | mother | - | constitute maternal complications | #6 |
maternal AGE levels | increase | intrauterine growth retardation, premature birth, neural tube defect, neurobehavioral developmental disorders, fetal death, and neonatal asphyxia | fetus | - | constitute fetal complications | #7 |
Excessive accumulation of advanced glycation end products (AGEs) in the body has been associated with many adverse health conditions. The common point of the pathologies associated at this point is oxidative stress and inflammation. Pregnancy is an important period in which many physiological, psychological, and biological changes are experienced. Along with the physiological changes that occur during this period, the mother maintaining an AGE-rich diet may cause an increase in the body's AGE pool and may increase oxidative stress and inflammation, as seen in healthy individuals. Studies have reported the negative effects of maternal AGE levels on maternal and fetal health during pregnancy. Although gestational diabetes, preeclampsia, endothelial dysfunction, and pelvic diseases constitute maternal complications, a number of pathological conditions such as intrauterine growth retardation, premature birth, neural tube defect, neurobehavioral developmental disorders, fetal death, and neonatal asphyxia constitute fetal complications. It is thought that the mechanisms of these complications have not been confirmed yet and more clinical studies are needed on this subject. The possible effects of dietary AGE levels during pregnancy on maternal and fetal health are examined in this review.