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Possible effects of dietary advanced glycation end products on maternal and fetal health: a review.

Nutrition reviews
January 1, 1970
Büşra Demirer et al. (2 authors)
ReviewJournal ArticleHuman Study
Study Details

Study Goal

The researchers aimed to examine the potential negative effects of dietary advanced glycation end products (AGEs) on maternal and fetal health during pregnancy.

Results Summary

The study suggests that excessive AGE accumulation may increase oxidative stress and inflammation, leading to adverse maternal and fetal outcomes such as gestational diabetes, preeclampsia, intrauterine growth retardation, and neurobehavioral developmental disorders. The mechanisms of these complications remain unconfirmed, requiring further clinical studies.

Population

Pregnant women and their fetuses.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (7)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Excessive accumulation of advanced glycation end products (AGEs)
increase
many adverse health conditions
-
-
has been associated with
#1
Excessive accumulation of advanced glycation end products (AGEs)
increase
oxidative stress and inflammation
-
-
associated at this point is
#2
maintaining an AGE-rich diet
increase
the body's AGE pool
mother
-
may cause an increase in
#3
maintaining an AGE-rich diet
increase
oxidative stress and inflammation
mother
-
may increase
#4
maternal AGE levels
decrease
maternal and fetal health during pregnancy
-
-
negative effects of
#5
maternal AGE levels
increase
gestational diabetes, preeclampsia, endothelial dysfunction, and pelvic diseases
mother
-
constitute maternal complications
#6
maternal AGE levels
increase
intrauterine growth retardation, premature birth, neural tube defect, neurobehavioral developmental disorders, fetal death, and neonatal asphyxia
fetus
-
constitute fetal complications
#7
Abstract

Excessive accumulation of advanced glycation end products (AGEs) in the body has been associated with many adverse health conditions. The common point of the pathologies associated at this point is oxidative stress and inflammation. Pregnancy is an important period in which many physiological, psychological, and biological changes are experienced. Along with the physiological changes that occur during this period, the mother maintaining an AGE-rich diet may cause an increase in the body's AGE pool and may increase oxidative stress and inflammation, as seen in healthy individuals. Studies have reported the negative effects of maternal AGE levels on maternal and fetal health during pregnancy. Although gestational diabetes, preeclampsia, endothelial dysfunction, and pelvic diseases constitute maternal complications, a number of pathological conditions such as intrauterine growth retardation, premature birth, neural tube defect, neurobehavioral developmental disorders, fetal death, and neonatal asphyxia constitute fetal complications. It is thought that the mechanisms of these complications have not been confirmed yet and more clinical studies are needed on this subject. The possible effects of dietary AGE levels during pregnancy on maternal and fetal health are examined in this review.

Medical Subject Headings (MeSH)
PregnancyInfant, NewbornFemaleHumansDietary Advanced Glycation End ProductsPrenatal CarePregnancy ComplicationsPre-EclampsiaGlycation End Products, AdvancedInflammation
Study Links
Quality Scores
Safety20
Quality65/10
Citation Metrics
Total Citations3
Citations/Year1.5
Relative Citation Ratio0.57
NIH Percentile30.7%
Research Impact Scores
APT Score0.25
Weight Score1.34
Normalized Score0.41
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