Effects of physical training on physical and functional fitness, physical activity level, endothelial function, hemodynamic variables, bone metabolism, and quality of life of post-bariatric patients: study protocol for a randomized controlled trial.
Study Goal
The researchers aimed to investigate the effects of a resistance training program on muscle mass, strength, bone health, and cardiovascular markers in post-bariatric surgery patients.
Results Summary
The study expects that resistance training will improve muscle mass and strength, bone metabolism, density, microarchitecture, quality of life, and cardiovascular risk factors, though final results are pending.
Population
60 physically inactive post-bariatric patients aged 18-50 years, ≥12 months post Roux-en-Y gastric bypass surgery.
Effective Dosage
60-minute sessions, 3 times/week
Duration
6 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
resistance training (RT) program | increase | muscle mass | post-bariatric patients | - | improving | #1 |
resistance training (RT) program | increase | muscle strength | post-bariatric patients | - | improving | #2 |
resistance training (RT) program | increase | bone metabolism | post-bariatric patients | - | improving | #3 |
resistance training (RT) program | increase | bone density | post-bariatric patients | - | improving | #4 |
resistance training (RT) program | increase | bone microarchitecture | post-bariatric patients | - | improving | #5 |
resistance training (RT) program | increase | health-related quality of life (QoL) | post-bariatric patients | - | improving | #6 |
resistance training (RT) program | decrease | cardiovascular risk | post-bariatric patients | - | improving | #7 |
BACKGROUND: Evidence of the benefits induced from resistance exercise on health markers of post-bariatric patients is limited. The study will investigate the effects of a resistance training (RT) program on muscle mass and strength, bone metabolism biomarkers, bone mineral density (BMD), bone microarchitecture, and endothelial function of patients subjected to Roux-en-Y gastric bypass. METHODS/DESIGN: This randomized controlled trial will include 60 post-bariatric patients, physically inactive, aging 18 to 50 years, with a post-surgery period ≥ 12 months. They will be randomly assigned into two groups: (i) the non-exercised control group, which will receive the standard clinical follow-up, or (ii) the intervention group which will consist of RT (60 min/session; 3 times/week, for 6 months). The primary outcomes will include muscle mass and strength, bone metabolism biomarkers, BMD, and bone microarchitecture. The secondary outcomes will be anthropometry, hemodynamic measurements, cardiovascular risk factors, health-related quality of life (QoL), and endothelial function. Outcomes will be assessed by blood biomarkers of bone formation and reabsorption, dual X-ray absorptiometry, repetition maximum and handgrip strength tests, high-resolution peripheral quantitative computed tomography, 36-Item Short-Form Health Survey, venous occlusion plethysmography, and nailfold videocapillaroscopy. DISCUSSION: It is expected that there are greater benefits from the RT program, possibly improving muscle mass and strength, bone metabolism, density and microarchitecture, QoL, and cardiovascular risk. TRIAL REGISTRATION: ClinicalTrials.gov NCT04193397. Registered on 7 December 2019.