Cannabidiol ameliorates the anxiogenic and compulsive-like behaviors induced by chronic consumption of a high-carbohydrate diet in male mice.
Study Goal
The researchers aimed to determine whether CBD treatment could mitigate compulsive-like and anxiety-like behaviors induced by chronic consumption of a high-refined carbohydrate (HC) diet in mice.
Results Summary
The study found that chronic HC diet consumption led to compulsive-like and anxiety-like behaviors in mice, and sub-chronic CBD treatment (but not acute) attenuated these effects. The results suggest CBD may have potential for treating psychiatric disorders linked to obesity.
Population
BALB/c male mice
Effective Dosage
30 mg/kg, intraperitoneal administration
Duration
12 weeks (HC diet) followed by CBD treatment
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
excessive consumption of ultra-processed foods and the development of obesity | increase | several comorbidities, including psychiatric disorders | - | - | has been associated with | #1 |
Excess fat tissue | increase | a low-intensity inflammatory state, mainly in the white tissue | - | - | promotes | #2 |
a low-intensity inflammatory state | increase | metabolic alterations | - | - | is essential in developing | #3 |
a low-intensity inflammatory state | neutral | brain homeostasis | - | - | influences | #4 |
Cannabidiol (CBD) | neutral | anxiolytic and anti-inflammatory effects | murine models | - | has presented | #5 |
chronic consumption of a high-refined carbohydrate (HC) diet | increase | compulsive-like and anxiety-like behaviors | mice | - | observed | #6 |
CBD treatment | decrease | the compulsive-like and anxiety-like behaviors | mice after chronic consumption of a high-refined carbohydrate (HC) diet | - | would ameliorate | #7 |
sub-chronic, but not acute, treatment with CBD | decrease | the compulsive-like and anxiogenic-like behavior | BALB/c male mice induced by the HC diet | - | attenuated | #8 |
chronic consumption of the HC diet | increase | compulsive and anxious behaviors | - | - | reinforced the harmful effects on | #9 |
CBD | neutral | a drug treatment for psychiatric disorders associated with obesity | - | - | has the potential as | #10 |
The excessive consumption of ultra-processed foods and the development of obesity has been associated with several comorbidities, including psychiatric disorders. Excess fat tissue promotes a low-intensity inflammatory state, mainly in the white tissue, which is essential in developing metabolic alterations and influences brain homeostasis. In this scenario, Cannabidiol (CBD), a compound from Cannabis sativa, has presented anxiolytic and anti-inflammatory effects in murine models. This study verified whether CBD treatment would ameliorate the compulsive-like and anxiety-like behaviors observed after mice's chronic consumption of a high-refined carbohydrate (HC) diet. BALB/c male mice received a control or HC diet for 12 weeks followed by vehicle and CBD (30 mg/Kg, i.p.) administration, and their behavior was evaluated in the Marble Burying test (MB) and Novel Suppressing Feeding test (NSF). The sub-chronic, but not acute, treatment with CBD attenuated the compulsive-like and anxiogenic-like behavior induced by the HC diet. Our data reinforced the harmful effects of the HC diet's chronic consumption on compulsive and anxious behaviors and the potential of CBD as a drug treatment for psychiatric disorders associated with obesity.