Arctostaphylos uva-ursi L. leaves extract and its modified cysteine preparation for the management of insulin resistance: chemical analysis and bioactivity.
Study Goal
The researchers aimed to investigate the chemical composition and effects of a dry alcohol extract from bearberry leaves, enriched with cysteine, on pancreatic function in rats with dexamethasone-induced insulin resistance.
Results Summary
The study found that the bearberry leaves extract, especially when enriched with cysteine, had hypoglycemic and pancreatic protective effects, improving hyperglycemia, insulin resistance, and beta cell reduction in the treated animals.
Population
Rats with dexamethasone-induced insulin resistance.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
bearberry leaves extract | decrease | blood glucose level | healthy animals under glucose overload | - | reduced | #1 |
dry alcohol extract from bearberry leaves enriched with cysteine | decrease | blood glucose | rats under experimental dexamethasone-induced insulin resistance | - | has a hypoglycaemic effect | #2 |
dry alcohol extract from bearberry leaves enriched with cysteine | neutral | pancreas | rats under experimental dexamethasone-induced insulin resistance | - | has a pancreatic protective effect | #3 |
Treatment | decrease | hyperglycaemia | treated animals under dexamethasone-induced IR model | - | improved | #4 |
Treatment | decrease | insulin resistance | treated animals under dexamethasone-induced IR model | - | improved | #5 |
Treatment | decrease | beta cell reduction | treated animals under dexamethasone-induced IR model | - | improved | #6 |
Bearberry (Arctostaphylos uva-ursi L.) is a perennial plant of the heather family (Ericaceae). The leaves are dominated by arbutin, phenol carbonic acids flavonoids, saponins, etc. It was previously shown that the bearberry leaves extract reduced blood glucose level in healthy animals under glucose overload, so it need to be studied more detail. The aim of the study was to investigate the chemical composition and the effect of dry alcohol extract from bearberry leaves, which enriched with cysteine, on the rats pancreas under experimental dexamethasone-induced insulin resistance (IR). Arctostaphylos uva-ursi L. leaves extract and its modified cysteine preparation were obtained according to the developed method with 50% ethanol solution. Their phytochemical profile, hypoglycaemic and pancreatic protective effect were investigated. Phenologlycoside (arbutin), phenolic carboxylic acid (gallic acid), 5 flavonoids and 4 hydroxycinnamic acids were identified and quantified in the extracts by HPLC. Present data revealed that bearberry leaves alcoholic dry extract enriched with cysteine has a hypoglycaemic and pancreatic protective effect in treated animals under dexamethasone-induced IR model. Treatment improved hyperglycaemia, insulin resistance and beta cell reduction induced by dexamethasone injections.