Effects of Walking Exercise at a Pace With Versus Without Ischemic Leg Symptoms on Functional Performance Measures in People With Lower Extremity Peripheral Artery Disease: The LITE Randomized Clinical Trial.
Study Goal
The researchers aimed to compare the effects of walking exercise that induces ischemic leg symptoms versus walking without such symptoms and a nonexercising control group on walking velocity and physical performance in people with peripheral artery disease.
Results Summary
Walking exercise that induced ischemic symptoms improved usual-paced walking velocity at 6 months compared to walking without ischemic symptoms, with a statistically significant difference (0.056 m/s [95% CI, 0.019-0.094 m/s]). The study did not report 12-month results in the provided abstract.
Population
Adults with peripheral artery disease (48% women, 61% Black race).
Effective Dosage
Not specified
Duration
12 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
home-based walking exercise that induced ischemic leg symptoms | increase | usual-paced walking velocity over 4 m | participants with peripheral artery disease | 0.056 m/s [95% CI, 0.019-0.094 m/s] | improved change in usual-paced walking velocity over 4 m | #1 |
Background In people with peripheral artery disease, post hoc analyses of the LITE (Low Intensity Exercise Intervention in Peripheral Artery Disease) randomized trial were conducted to evaluate the effects of walking exercise at a pace inducing ischemic leg symptoms on walking velocity and the Short Physical Performance Battery, compared with walking exercise without ischemic leg symptoms and compared with a nonexercising control group. Methods and Results Participants with peripheral artery disease were randomized to: home-based walking exercise that induced ischemic leg symptoms; home-based walking exercise conducted without ischemic leg symptoms; or a nonexercising control group for 12 months. Outcomes were change of walking velocity over 4 m and change of the Short Physical Performance Battery (0-12, with 12=best) at 6- and 12-month follow-up. A total of 264 participants (48% women, 61% Black race) were included. Compared with walking exercise without ischemic symptoms, walking exercise that induced ischemic symptoms improved change in usual-paced walking velocity over 4 m at 6-month (0.056 m/s [95% CI, 0.019-0.094 m/s];